Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 87317, Iran.
Ultrason Sonochem. 2014 Jul;21(4):1451-60. doi: 10.1016/j.ultsonch.2014.02.014. Epub 2014 Feb 24.
A convenient one-pot protocol was developed for the synthesis of 1H-spiro[furo[3,4-b]pyridine-4,3'-indoline]-3-carbonitrile derivatives. This reaction was carried out through a three component condensation reaction of isatins, malononitrile, and anilinolactones in the presence of a catalytic amount of Et3N as an inexpensive and available basic catalyst in THF under ultrasound irradiation. The products were obtained in high yields and short reaction times. The main advantage of this synthetic method is that the obtained products in ultrasonic irradiations are different from classical heating.
开发了一种方便的一锅法，用于合成 1H-螺[furo[3,4-b]吡啶-4,3'-吲哚]-3-腈衍生物。该反应是通过在超声辐射下，三组分缩合反应，将色酮、丙二腈和苯并内酰胺在催化量的三乙胺作为廉价易得的碱性催化剂存在下，在四氢呋喃中进行的。产物以高产率和短反应时间获得。该合成方法的主要优点是，在超声辐射下获得的产物与经典加热不同。
