直击其生存之地：靶向胶质母细胞瘤血管周围干细胞微环境
Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche.
作者信息
Brooks Michael D, Sengupta Rajarshi, Snyder Steven C, Rubin Joshua B
机构信息
Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Ave. St Louis, MO 63110.
出版信息
Curr Pathobiol Rep. 2013 Jun 1;1(2):101-110. doi: 10.1007/s40139-013-0012-0.
Abstract
Glioblastoma growth potential and resistance to therapy is currently largely attributed to a subset of tumor cells with stem-like properties. If correct, this means that cure will not be possible without eradication of the stem cell fraction and abrogation of those mechanisms through which stem cell activity is induced and maintained. Glioblastoma stem cell functions appear to be non-cell autonomous and the consequence of tumor cell residence within specialized domains such as the perivascular stem cell niche. In this review we consider the multiple cellular constituents of the perivascular niche, the molecular mechanisms that support niche structure and function and the implications of the perivascular localization of stem cells for anti-angiogenic approaches to cure.
摘要
目前，胶质母细胞瘤的生长潜力和对治疗的抗性在很大程度上归因于具有干细胞样特性的肿瘤细胞亚群。如果这一观点正确，那就意味着，若不根除干细胞部分并消除诱导和维持干细胞活性的机制，治愈将是不可能的。胶质母细胞瘤干细胞的功能似乎并非细胞自主的，而是肿瘤细胞驻留在诸如血管周围干细胞微环境等特定区域的结果。在这篇综述中，我们探讨了血管周围微环境的多种细胞成分、支持微环境结构和功能的分子机制，以及干细胞的血管周围定位对治愈性抗血管生成方法的影响。
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