胶质母细胞瘤干细胞：通过混沌驱动韧性。
Glioblastoma Stem Cells: Driving Resilience through Chaos.
机构信息
Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, 44195, USA; Case Western Reserve University Medical Scientist Training Program, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA.
出版信息
Trends Cancer. 2020 Mar;6(3):223-235. doi: 10.1016/j.trecan.2020.01.009. Epub 2020 Feb 3.
Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells (GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance. The high entropy of GSCs is driven by a permissive epigenetic landscape and a mutational landscape that revokes crucial cellular checkpoints. The GSC population encompasses a complex array of diverse microstates that are defined and maintained by a wide variety of attractors including the complex tumor ecosystem and therapeutic intervention. Constant dynamic transcriptional fluctuations result in a highly adaptable and heterogeneous entity primed for therapy evasion and survival. Analyzing the transcriptional, epigenetic, and metabolic landscapes of GSC dynamics in the context of a stochastically fluctuating tumor network will provide novel strategies to target resistant populations of GSCs in glioblastoma.
胶质母细胞瘤是一种侵袭性和异质性肿瘤，其中胶质母细胞瘤干细胞（GSCs）处于熵等级的顶端，并赋予其毁灭性的治疗抵抗性。GSCs 的高熵是由允许的表观遗传景观和突变景观驱动的，这种景观取消了关键的细胞检查点。GSC 群体包含一系列复杂的不同微状态，这些微状态由多种吸引子定义和维持，包括复杂的肿瘤生态系统和治疗干预。不断的动态转录波动导致了一个高度适应和异质的实体，为逃避治疗和生存做好了准备。在随机波动的肿瘤网络的背景下分析 GSC 动力学的转录、表观遗传和代谢景观，将为靶向胶质母细胞瘤中具有抵抗性的 GSC 群体提供新的策略。
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