School of Life Sciences, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, UK.
Trials. 2013 Jun 14;14:173. doi: 10.1186/1745-6215-14-173.
Over recent decades there has been a substantial increase in asthma and allergic disease especially in children. Given the high prevalence, and the associated high disease burden and costs, there is a need to identify effective strategies for the primary prevention of asthma and allergy. A recent systematic review of the literature found strong supportive epidemiological evidence for a protective role of the Mediterranean diet, which now needs to be confirmed through formal experimental studies. This pilot trial in pregnant women aims to establish recruitment, retention and acceptability of a dietary intervention, and to assess the likely impact of the intervention on adherence to a Mediterranean diet during pregnancy.
METHODS/DESIGN: This study was a pilot, two-arm, randomised controlled trial in a sample population of pregnant women at high risk of having a child who will develop asthma or allergic disease.
The work ultimately aims to contribute to improving health outcomes through seeking to reduce the incidence of asthma and allergic problems. This pilot trial will prove invaluable in informing the subsequent planned large-scale, parallel group, randomised controlled trial.
近几十年来，哮喘和过敏性疾病的发病率显著上升，尤其是在儿童中。鉴于其高患病率，以及相关的高疾病负担和高治疗费用，我们需要确定预防哮喘和过敏的有效策略。最近对文献的系统综述发现，地中海饮食对预防哮喘和过敏具有很强的支持性流行病学证据，现在需要通过正式的实验研究来证实。这项针对孕妇的试验旨在确定饮食干预措施的招募、保留和可接受性，并评估该干预措施对孕妇遵循地中海饮食的影响。
方法/设计：这是一项针对高危孕妇的两臂随机对照试验，这些孕妇有较高的风险生育患有哮喘或过敏性疾病的孩子。
该研究最终旨在通过降低哮喘和过敏问题的发生率来改善健康结果。这项试验将为随后计划的大规模平行组随机对照试验提供宝贵的信息。
