Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Tykistökatu 6A, FI-20520 Turku, Finland.
Int J Pharm. 2013 Sep 10;453(2):488-97. doi: 10.1016/j.ijpharm.2013.06.003. Epub 2013 Jun 14.
The primary goal of the current work was to study the applicability of precision inkjet printing in fabrication of personalized doses of active pharmaceutical ingredients (APIs). Loperamide hydrochloride (LOP) and caffeine (CAF) were used as model compounds. Different doses of the drugs in a single dosage unit were produced, using a drop-on-demand inkjet printer by varying printing parameters such as the distance between jetted droplets (drop spacing) and the physical dimensions of the printed dosage forms. The behavior of the formulated printable inks for both APIs was investigated on the model substrates, using different analytical tools. The obtained results showed that printed LOP did not recrystallize on any substrates studied, whereas at least partial recrystallization of printed CAF was observed on all carrier surfaces. Flexible doses of both APIs were easily obtained by adjusting the drop spacing of the depositing inks, and the results were relevant with regards to the theoretical content. Adapting the dose by varying physical dimensions of single dosage units was less successful than the approach in which drop spacing was altered. In conclusion, controlled printing technology, by means of adjusting the distance between jetted droplets, offers a means to fabricate dosage forms with individualized doses.
本研究的主要目的是研究精密喷墨打印在制备活性药物成分（APIs）个性化剂量中的适用性。盐酸洛哌丁胺（LOP）和咖啡因（CAF）被用作模型化合物。使用按需喷墨打印机，通过改变打印参数，如喷射液滴之间的距离（滴距）和打印剂型的物理尺寸，在单个剂型中产生不同剂量的药物。使用不同的分析工具，研究了两种 API 的配方可打印墨水在模型基底上的行为。结果表明，在研究的所有载体表面上，打印的 LOP 都没有再结晶，而打印的 CAF 至少部分再结晶。通过调整沉积墨水的滴距，很容易获得两种 API 的柔性剂量，并且结果与理论含量相关。通过改变单个剂型的物理尺寸来调整剂量的方法不如改变滴距的方法成功。总之，通过调整喷射液滴之间的距离来控制打印技术，为制备个体化剂量的剂型提供了一种手段。
