Turković Erna, Vasiljević Ivana, Drašković Milica, Obradović Nataša, Vasiljević Dragana, Parojčić Jelena
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Department of Chemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia.
Pharmaceutics. 2021 Mar 30;13(4):468. doi: 10.3390/pharmaceutics13040468.
Inkjet printing is novel approach in drug manufacturing that enables dispensing precise volumes of ink onto substrates. Optimal substrate properties including suitable mechanical characteristic are recognized as crucial to achieve desired dosage form performance upon administration. Identification of relevant quality attributes and their quantification is subject of intensive scientific research. The aim of this work was to explore applicability of different materials as printing substrates and explore contribution of the investigated substrate properties to its printability. Substrates were characterized with regards to uniformity, porosity, disintegration time, mechanical properties and drug dissolution. Experimentally obtained values were mathematically transformed and the obtained results were presented as relevant radar charts. It was shown that structurally different substrates may be employed for orodispersible films inkjet printing. Main disadvantage of single-polymer films was low drug load, and their printability was dependent on film flexibility and mechanical strength. Structured orodispersible film templates exhibited favorable mechanical properties and drug load capacity. Wafer edible sheets were characterized with high mechanical resistance and brittleness which somewhat diminished printability, but did not hinder high drug load. Obtained results provide insight into application of different materials as printing substrates and contribute to understanding of substrate properties which can affect printability.
喷墨印刷是药物制造中的一种新方法，它能够将精确体积的油墨分配到基材上。包括合适机械特性在内的最佳基材特性被认为对于给药后实现所需剂型性能至关重要。识别相关质量属性及其量化是深入科学研究的主题。这项工作的目的是探索不同材料作为印刷基材的适用性，并探究所研究的基材特性对其可印刷性的贡献。对基材的均匀性、孔隙率、崩解时间、机械性能和药物溶出度进行了表征。将实验获得的值进行数学转换，并将所得结果以相关雷达图的形式呈现。结果表明，结构不同的基材可用于口腔崩解膜的喷墨印刷。单聚合物膜的主要缺点是载药量低，其可印刷性取决于膜的柔韧性和机械强度。结构化口腔崩解膜模板具有良好的机械性能和载药能力。薄脆可食用片材具有高机械抗性和脆性，这在一定程度上降低了可印刷性，但不妨碍高载药量。所得结果为不同材料作为印刷基材的应用提供了见解，并有助于理解可能影响可印刷性的基材特性。
