Sasaki Sei, Yui Naofumi, Noda Yumi
Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
Biochim Biophys Acta. 2014 Feb;1838(2):514-20. doi: 10.1016/j.bbamem.2013.06.004. Epub 2013 Jun 14.
The interplay between actin and 10 membrane channel proteins that have been shown to directly bind to actin are reviewed. The 10 membrane channel proteins covered in this review are aquaporin 2 (AQP2), cystic fibrosis transmembrane conductance regulator (CFTR), ClC2, short form of ClC3 (sClC3), chloride intracellular channel 1 (CLIC1), chloride intracellular channel 5 (CLIC5), epithelial sodium channel (ENaC), large-conductance calcium-activated potassium channel (Maxi-K), transient receptor potential vanilloid 4 (TRPV4), and voltage-dependent anion channel (VDAC), with particular attention to AQP2. In regard to AQP2, most reciprocal interactions between actin and AQP2 occur during intracellular trafficking, which are largely mediated through indirect binding. Actin and the actin cytoskeleton work as cables, barriers, stabilizers, and force generators for motility. However, as with ENaC, the effects of actin cytoskeleton on channel gating should be investigated further. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Hervé.
本文综述了肌动蛋白与已被证明可直接结合肌动蛋白的10种膜通道蛋白之间的相互作用。本综述涵盖的10种膜通道蛋白分别是水通道蛋白2（AQP2）、囊性纤维化跨膜传导调节因子（CFTR）、氯离子通道蛋白2（ClC2）、氯离子通道蛋白3短型（sClC3）、细胞内氯离子通道1（CLIC1）、细胞内氯离子通道5（CLIC5）、上皮钠通道（ENaC）、大电导钙激活钾通道（Maxi-K）、瞬时受体电位香草酸受体4（TRPV4）和电压依赖性阴离子通道（VDAC），其中对AQP2给予了特别关注。关于AQP2，肌动蛋白与AQP2之间的大多数相互作用发生在细胞内运输过程中，这在很大程度上是通过间接结合介导的。肌动蛋白和肌动蛋白细胞骨架起到电缆、屏障、稳定剂和运动力发生器的作用。然而，与ENaC一样，肌动蛋白细胞骨架对通道门控的影响仍需进一步研究。本文是名为：细胞骨架与膜通道、受体和转运体之间的相互影响的特刊的一部分。客座编辑：让·克洛德·埃尔韦。
