队列简介：诺福克郡老年男性和女性人群客观身体和认知能力及视觉健康的前瞻性队列研究（欧洲癌症与营养前瞻性调查诺福克 3 期）
Cohort profile: A prospective cohort study of objective physical and cognitive capability and visual health in an ageing population of men and women in Norfolk (EPIC-Norfolk 3).
作者信息
Hayat Shabina A, Luben Robert, Keevil Victoria L, Moore Stephanie, Dalzell Nichola, Bhaniani Amit, Khawaja Anthony P, Foster Paul, Brayne Carol, Wareham Nicholas J, Khaw Kay-Tee
机构信息
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK, NIHR Biomedical Research Centre at Moorfields Eye Hospital and University College London, London, UK, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK and MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
出版信息
Int J Epidemiol. 2014 Aug;43(4):1063-72. doi: 10.1093/ije/dyt086. Epub 2013 Jun 14.
The European Prospective Investigation of Cancer (EPIC) is a 10-country collaborative study in which EPIC-Norfolk is one of the UK centres. EPIC-Norfolk examined 25 639 men and women resident in East Anglia (aged 40-79 years), between 1993 and 1997. The EPIC collaboration was set up to examine the dietary determinants of cancer, but the remit in the EPIC-Norfolk cohort was broadened from the outset to include determinants of other health conditions and chronic diseases. EPIC-Norfolk completed a third round of health examinations (EPIC-Norfolk 3 or 3HC) in December 2011, on 8623 participants in the age range 48-92 years. EPIC-Norfolk focused on objective measures of cognitive function, physical capability and visual health, adapting this existing mid-life cohort to the current need to investigate healthy and independent living for ageing societies. With a wealth of longitudinal data and a biobank (including DNA) collected at up to three separate time points, EPIC-Norfolk offers the unique opportunity to investigate the association of lifestyle and biological factors, including genetic exposures, with a range of health outcomes in middle and later life. Information for data access can be found on the study website, details as given in this cohort profile.
欧洲癌症前瞻性调查（EPIC）是一项由10个国家参与的合作研究，其中诺福克郡EPIC研究是英国的研究中心之一。诺福克郡EPIC研究在1993年至1997年间，对居住在东安格利亚地区（年龄在40 - 79岁之间）的25639名男性和女性进行了调查。EPIC合作项目旨在研究癌症的饮食决定因素，但诺福克郡EPIC队列研究从一开始就扩大了范围，将其他健康状况和慢性病的决定因素也纳入其中。诺福克郡EPIC研究于2011年12月对年龄在48 - 92岁之间的8623名参与者完成了第三轮健康检查（诺福克郡EPIC研究3或3HC）。诺福克郡EPIC研究专注于认知功能、身体能力和视觉健康的客观测量，使这个现有的中年队列适应目前为老龄化社会研究健康和独立生活的需求。凭借在多达三个不同时间点收集的丰富纵向数据和生物样本库（包括DNA），诺福克郡EPIC研究提供了一个独特的机会，来研究生活方式和生物因素（包括基因暴露）与中年及老年一系列健康结果之间的关联。有关数据访问的信息可在研究网站上找到，本队列简介中给出了详细信息。
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