Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
J Korean Med Sci. 2013 Jun;28(6):855-60. doi: 10.3346/jkms.2013.28.6.855. Epub 2013 Jun 3.
There have been many studies between serum uric acid (UA) and chronic kidney disease (CKD). However, as far as we know, little research has been done to examine the prospective association between serum UA and development of CKD in Korean men. This prospective cohort study was performed using 18,778 men who participated in a health checkup program both on January, 2005 and on December, 2009. CKD was defined as an estimated glomerular filtration rate < 60 mL/min per 1.73 m(2). The odds ratio (OR) from binary logistic regressions for the development of CKD was determined with respect to the quintiles grouping based on serum UA. During 74,821.4 person-years of follow-up, 110 men were found to develop CKD. The OR for the development of CKD increased as the quintiles for baseline serum UA levels increased from the first to fifth quintiles (1.00 vs 1.22, 1.19, 2.59, and 3.03, respectively, p for linear trend < 0.001) after adjusting for covariates. The adjusted OR comparing those participants with hyperuricemia ( ≥ 7.0 mg/dL) to those with normouricemia ( < 7.0 mg/dL) was 1.96 (1.28-2.99). Elevated serum UA levels were independently associated with increased likelihood for the development of CKD in Korean men (IRB number: KBC10034).
已有许多关于血清尿酸（UA）与慢性肾脏病（CKD）之间的研究。然而，据我们所知，针对韩国男性血清 UA 与 CKD 发展之间的前瞻性关联，几乎没有研究进行。本前瞻性队列研究纳入了 18778 名于 2005 年 1 月和 2009 年 12 月参加健康体检计划的男性。CKD 的定义为估算肾小球滤过率（eGFR）<60 mL/min/1.73m²。采用二元逻辑回归分析，根据血清 UA 五分位组，确定了 CKD 发展的比值比（OR）。在 74821.4 人年的随访期间，有 110 名男性被诊断为 CKD。在校正了协变量后，随着基线血清 UA 水平五分位从第一到第五分位（1.00 比 1.22、1.19、2.59 和 3.03，p 值趋势检验<0.001），CKD 发展的 OR 逐渐升高。与正常尿酸血症（<7.0 mg/dL）相比，患有高尿酸血症（≥7.0 mg/dL）的参与者发生 CKD 的调整后 OR 为 1.96（1.28-2.99）。血清 UA 水平升高与韩国男性 CKD 发生的可能性增加独立相关（IRB 编号：KBC10034）。
