Hong Wei, Dumoff Kimberly L, Torigian Drew A, Bing Zhanyong
Department of Pathology and Laboratory Medicine, Conemaugh Memorial Medical Center, Johnstown, PA;
Rare Tumors. 2013 Feb 12;5(1):e1. doi: 10.4081/rt.2013.e1. Print 2013 Feb 11.
Teratomas are characterized by containing tissue from all three germinal cell layers. Occasionally, somatic type malignancies develop within a mature cystic teratoma. We reported here a rare case of enteric type adenocarcinoma, with associated dysplastic epithelial precursor lesion, arising within a mature cystic teratoma in the retroperitoneum of a 30-year-old woman status post vaginal delivery 11 weeks earlier. The mass is 17.5 cm and cystic. A polypoid mass component measuring 4.7×4.2×2.5 cm was located inside the cystic component. Microscopically, the majority of the specimen was a mature cystic teratoma with all three germinal cell layers. The polypoid mass component was an adenocarcinoma with an adjacent dysplastic epithelial precursor lesion. The adenocarcinoma was diffusely positive for CK20 and CDX-2, and focally positive for CD7, indicating enteric differentiation. A brief review of retroperitoneal mature cystic teratomas with associated somatic type malignancy was performed.
畸胎瘤的特征是包含来自所有三个胚层的组织。偶尔，成熟囊性畸胎瘤内会发生体细胞型恶性肿瘤。我们在此报告了一例罕见的肠型腺癌病例，伴有发育异常的上皮前体病变，发生在一名30岁女性的成熟囊性畸胎瘤内，该女性在11周前经阴道分娩。肿块为17.5厘米，呈囊性。一个大小为4.7×4.2×2.5厘米的息肉样肿块位于囊性成分内。显微镜下，大部分标本为具有所有三个胚层的成熟囊性畸胎瘤。息肉样肿块成分是腺癌，伴有相邻的发育异常上皮前体病变。腺癌对CK20和CDX - 2弥漫性阳性，对CD7局灶性阳性，表明为肠分化。对伴有体细胞型恶性肿瘤的腹膜后成熟囊性畸胎瘤进行了简要回顾。
