Drago Matthew J, Kim Brian S, Bennett Daniel, Elder David, Rosenbach Misha
School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cutis. 2013 May;91(5):246-7.
Acute promyelocytic leukemia (APL) accounts for 10% of acute myelocytic leukemias and is characterized by t(15;17) that produces the PML-RARα (promyelocytic leukemia-retinoic acid receptor α) fusion oncoprotein. The discovery and implementation of all-trans-retinoic acid (ATRA) therapy for APL has led to complete remission rates greater than 90% when coupled with chemotherapy. We report a novel case of ATRA-induced scrotal ulcers in a black man with APL. The differential diagnosis of scrotal ulcerations in immunocompromised patients is lengthy, and misdiagnosis can lead to substantial morbidity and mortality. It is important for dermatologists to be aware of this potential complication of ATRA therapy.
急性早幼粒细胞白血病（APL）占急性髓细胞白血病的10%，其特征为t(15;17)，该染色体易位产生PML-RARα（早幼粒细胞白血病-维甲酸受体α）融合癌蛋白。全反式维甲酸（ATRA）疗法应用于APL的发现与实施，使其与化疗联合使用时完全缓解率超过90%。我们报告了1例患有APL的黑人男性出现ATRA诱导的阴囊溃疡的新病例。免疫功能低下患者阴囊溃疡的鉴别诊断范围广泛，误诊会导致严重的发病率和死亡率。皮肤科医生了解ATRA治疗的这一潜在并发症很重要。
