全反式维甲酸治疗急性早幼粒细胞白血病期间出现的阴囊溃疡

Scrotal Ulcers Arising during Treatment with All-trans Retinoic Acid for Acute Promyelocytic Leukemia.

作者信息

Shimizu Daisuke, Nomura Kenichi, Matsuyama Ryuzo, Matsumoto Yosuke, Ueda Kyoji, Masuda Koji, Taki Tomohiko, Nishida Kazuhiro, Horiike Shigeo, Kishimoto Saburo, Yanagisawa Akio, Taniwaki Masafumi

机构信息

Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Japan.

出版信息

Intern Med. 2005 May;44(5):480-3. doi: 10.2169/internalmedicine.44.480.

DOI:10.2169/internalmedicine.44.480

PMID:15942099

Abstract

All-trans retinoic acid (ATRA) is effective in approximately 90% of the cases of acute promyelocytic leukemia (APL) with a low incidence of adverse effects. We report a patient with APL who developed skin ulcers of the scrotum concomitant with high fever during treatment that included ATRA. Severe fever was promptly alleviated with discontinuation of ATRA, while the ulcers improved gradually over 3 months. As the clinical features are similar to those of Sweet's syndrome, we should be aware of the possibility that this rare adverse effect may occur in the treatment with ATRA.

摘要

全反式维甲酸（ATRA）对约90%的急性早幼粒细胞白血病（APL）病例有效，且不良反应发生率较低。我们报告1例APL患者，在包括ATRA的治疗过程中出现阴囊皮肤溃疡并伴有高热。停用ATRA后，高热迅速缓解，而溃疡在3个月内逐渐好转。由于临床特征与Sweet综合征相似，我们应意识到在ATRA治疗中可能会出现这种罕见的不良反应。