大根香叶中的生物活性萜类化合物。

Bioactive terpenoids from the fruits of Aphanamixis grandifolia.

机构信息

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

出版信息

J Nat Prod. 2013 Jun 28;76(6):1191-5. doi: 10.1021/np400126q. Epub 2013 Jun 17.

DOI:10.1021/np400126q

PMID:23772699

Abstract

From the fruits of the tropical tree Aphanamixis grandifolia, five new evodulone-type limonoids, aphanalides I-M (1-5), one new apo-tirucallane-type triterpenoid, polystanin E (6), and three new chain-like diterpenoids, nemoralisins A-C (7-9), along with 12 known compounds were identified. The absolute configurations were determined by a combination of single-crystal X-ray diffraction studies, Mo2(OAc)4-induced electronic circular dichroism (ECD) data, the Mosher ester method, and calculated ECD data. The cytotoxicities of all the isolates and the insecticidal activities of the limonoids were evaluated.

摘要

从热带树木 Aphanamixis grandifolia 的果实中，分离得到了五个新的吴茱萸内酯型柠檬苦素，即 aphanalides I-M（1-5），一个新的无柄倍半萜型三萜，polystanin E（6），以及三个新的链状二萜，nemoralisins A-C（7-9），此外还鉴定出了 12 种已知化合物。通过单晶 X 射线衍射研究、Mo2(OAc)4 诱导的电子圆二色性（ECD）数据、莫什酯法和计算 ECD 数据的组合，确定了它们的绝对构型。评估了所有分离物的细胞毒性和柠檬苦素的杀虫活性。