Department of Medicine II, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Diagn Microbiol Infect Dis. 2013 Sep;77(1):79-84. doi: 10.1016/j.diagmicrobio.2013.05.005. Epub 2013 Jun 14.
This study evaluates potential markers in blood and stools for their ability to distinguish bacterial from viral gastroenteritis. A total of 108 patients were prospectively recruited, of which 27 showed bacterial, 30 viral, and 51 no detectable pathogen, respectively. Cytokines, C-reactive protein (CRP), and white blood cells as well as the 2 fecal markers lactoferrin and calprotectin were determined. Statistics comprised Kruskal-Wallis test and U test in addition to an assessment of receiver operating characteristic. Interferon γ (IFNγ) levels were significantly increased in the viral group compared to the bacterial and nonspecific group. For the bacterial group, both fecal markers lactoferrin and calprotectin as well as CRP were significantly higher in comparison to the other 2 groups. To differentiate between bacterial and viral gastroenteritis, CRP, serum IFNγ, and the fecal proteins lactoferrin and calprotectin may be useful. A corresponding algorithm should be evaluated prospectively.
本研究评估了血液和粪便中的潜在标志物，以其区分细菌和病毒性胃肠炎的能力。总共前瞻性招募了 108 名患者，其中分别有 27 例为细菌性、30 例为病毒性和 51 例未检测到病原体。测定了细胞因子、C 反应蛋白（CRP）和白细胞以及 2 种粪便标志物乳铁蛋白和钙卫蛋白。统计分析包括 Kruskal-Wallis 检验和 U 检验，以及对受试者工作特征的评估。与细菌性和非特异性组相比，病毒性组的干扰素 γ（IFNγ）水平显著升高。对于细菌性组，与其他 2 组相比，粪便标志物乳铁蛋白和钙卫蛋白以及 CRP 均显著升高。为了区分细菌性和病毒性胃肠炎，CRP、血清 IFNγ 和粪便蛋白乳铁蛋白和钙卫蛋白可能有用。应前瞻性评估相应的算法。
