Alhazmi Hazem, Alzahrani Abeer, Alshaikh Saud, Azzhary Lein, Alhaddad Fatimah, Alshamrani Zeyad, Alwagdani Raghad
Pediatric Emergency Department, NGHA, Jeddah 11426, Saudi Arabia.
King Abdullah's Specialized Children Hospital, Jeddah 11426, Saudi Arabia.
Children (Basel). 2025 May 9;12(5):617. doi: 10.3390/children12050617.
Considerable mortality and morbidity rates linked to AGE are well documented in the literature. Many inflammatory markers have been studied in the context of research on AGE as tools to predict the clinical course of the disease and determine the need for the use of antimicrobials. This study focuses on CRP, PCT, and WBC counts as inflammatory markers of AGE. A retrospective chart review study was conducted at King Abdullah Specialized Children's Hospital, Jeddah. Using a non-probability consecutive sampling technique, all patients under the age of 14 diagnosed with gastroenteritis over four years (2020-2024) were included. The sample population consisted of 84 individuals. Pathogen prevalence was identified in only 15%. was the most frequently identified bacterial pathogen. While the WBC count and ESR were reassuring in most cases, the CRP and PCT measurements were almost always elevated. Compared to the stronger association observed with WBC counts, the correlation between PCT levels and ED visits were less significant. Higher CRP levels were associated with an increased use of antibiotics. The results of this study highlight that CRP is useful in identifying patients who are likely to have bacterial AGE and require antibiotics. Moreover, the WBC count is a helpful tool in predicting those likely to present to the ED again.
文献中已充分记录了与急性胃肠炎（AGE）相关的相当高的死亡率和发病率。在关于AGE的研究中，许多炎症标志物已被作为预测疾病临床进程和确定是否需要使用抗菌药物的工具进行了研究。本研究聚焦于CRP、PCT和白细胞计数作为AGE的炎症标志物。在吉达的阿卜杜拉国王专科医院进行了一项回顾性病历审查研究。采用非概率连续抽样技术，纳入了所有在四年（2020 - 2024年）内被诊断为胃肠炎的14岁以下患者。样本群体由84人组成。仅15%的病例确定了病原体流行情况。是最常被鉴定出的细菌病原体。虽然在大多数情况下白细胞计数和血沉结果令人安心，但CRP和PCT测量值几乎总是升高。与观察到的白细胞计数更强的关联相比，PCT水平与急诊就诊之间的相关性不太显著。较高的CRP水平与抗生素使用增加有关。本研究结果表明，CRP有助于识别可能患有细菌性AGE且需要使用抗生素的患者。此外，白细胞计数是预测那些可能再次前往急诊室患者的有用工具。
