Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, Santiago, Chile.
Horm Res Paediatr. 2013;79(6):347-55. doi: 10.1159/000351466. Epub 2013 Jun 11.
Rapid early ponderal growth is associated with adverse metabolic risks in young adults born at term.
To determine whether there are differences in body composition, resting energy expenditure (REE) and metabolic variables between preterm children born with very low birth weight (VLBW) either appropriate (AGA) or small (SGA) for gestational age and whether these differences are related to an early period of weight gain.
67 VLBW preterm (40 AGA, 27 SGA). Body composition by DEXA, REE by indirect calorimetry and blood sampling at age 6.7 ± 0.5 years.
VLBW SGA children were lighter, shorter, had a lower waist and hip circumference, HDL cholesterol and lipid oxidation rates than their AGA counterparts (adjusted for age, sex and BMI). Birth weight correlated negatively with total body and trunk fat mass. In a multivariate linear regression analysis, we found a positive association between weight gain in the first 3 months of life and total and trunk fat at age 6 years and a reciprocal association with REE at age 6 years. In contrast, the weight gain rate at 6-9 months of life was associated with higher REE and lipid oxidation rates at 6 years. A higher weight gain rate at 9-12 months was associated with a higher lean mass at 6 years.
An early fast-pace weight gain in VLBW infants may have detrimental consequences for metabolic health later on.
在足月出生的成年人中，快速早期体重增长与不良代谢风险相关。
确定出生体重极低（VLBW）且胎龄适当（AGA）或较小（SGA）的早产儿之间，其身体成分、静息能量消耗（REE）和代谢变量是否存在差异，以及这些差异是否与早期体重增长有关。
67 名 VLBW 早产儿（40 名 AGA，27 名 SGA）。在年龄为 6.7±0.5 岁时，通过 DEXA 测量身体成分，通过间接热量法测量 REE，并进行血液采样。
VLBW SGA 儿童体重较轻、身高较矮、腰围和臀围较小，HDL 胆固醇和脂质氧化率低于 AGA 儿童（根据年龄、性别和 BMI 进行调整）。出生体重与全身和躯干脂肪量呈负相关。在多元线性回归分析中，我们发现生命前 3 个月的体重增长与 6 岁时的全身和躯干脂肪量呈正相关，与 6 岁时的 REE 呈负相关。相反，6-9 个月时的体重增长率与 6 岁时的 REE 和脂质氧化率较高相关。9-12 个月时的体重增长率与 6 岁时的瘦体重较高相关。
VLBW 婴儿早期快速增重可能对其后期代谢健康产生不利影响。
