从印度瓦拉纳西采集的微囊藻水华材料中分离到的鱼腥藻素。

Aeruginosins from a Microcystis sp. bloom material collected in Varanasi, India.

机构信息

Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv 69978, Israel.

出版信息

J Nat Prod. 2013 Jun 28;76(6):1187-90. doi: 10.1021/np4001152. Epub 2013 Jun 18.

DOI:10.1021/np4001152

PMID:23777401

Abstract

Two novel biologically active short peptides, aeruginosins IN608 and IN652, were isolated from the cyanobacterium Microcystis sp. strain BHU006, which was collected from Durgakund water reservoir in Varanasi, India. Aeruginosins IN608 and IN652 are linear modified peptides containing four building blocks, one of which is the arogenate-derived modified amino acid 2-carboxy-6-hydroxyoctahydroindole. Aeruginosin IN608 and aeruginosin IN652 inhibit the activity of the proteolytic enzyme trypsin with IC50's of 4.3 and 4.1 μM, respectively.

摘要

从印度瓦拉纳西的杜尔加昆德水库采集的蓝藻 Microcystis sp. 菌株 BHU006 中分离得到两种新型生物活性短肽 aeruginosins IN608 和 IN652。 aeruginosins IN608 和 IN652 是含有四个结构单元的线性修饰肽，其中一个是来源于阿罗酮糖的修饰氨基酸 2-羧基-6-羟基八氢吲哚。 aeruginosin IN608 和 aeruginosin IN652 对蛋白酶胰蛋白酶的活性具有抑制作用，IC50 值分别为 4.3 和 4.1 μM。