Department of Biochemistry and Biomedical Sciences, M.G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
J Antibiot (Tokyo). 2013 Jul;66(7):443-6. doi: 10.1038/ja.2013.52. Epub 2013 Jun 19.
Macplocimine A (1), a rare naturally occurring 18-membered macrolide, was isolated from the marine-derived filamentous sulfur bacteria Thioploca sp. The structure was determined by a combination of spectroscopic techniques, including HRESIMS, 1D and 2D NMR analyses. 1 features a thymine group, which is attached to an aromatic fused 18-membered macrolide ring structure derived from a polyketide synthase biosynthetic pathway.
Macplocimine A（1）是一种罕见的天然存在的 18 元大环内酯，从海洋来源的丝状硫细菌硫发菌属（Thioploca sp.）中分离得到。通过结合高分辨质谱（HRESIMS）、1D 和 2D NMR 分析等光谱技术确定了其结构。1 具有一个胸腺嘧啶基团，连接到一个芳香稠合的 18 元大环内酯环结构，该结构来源于聚酮合酶生物合成途径。
