Corresponding author: Kyung Mook Choi,
Diabetes Care. 2013 Oct;36(10):3321-7. doi: 10.2337/dc13-0178. Epub 2013 Jun 18.
To examine the effect of a combined exercise program on C1q/tumor necrosis factor-related protein (CTRP) 3 and CTRP-5 levels and novel adiponectin paralogs suggested to be links between metabolism and inflammation and to evaluate sex differences and association with cardiometabolic risk factors in humans with use of a newly developed ELISA.
This cross-sectional study explored the implications of CTRP-3 and CTRP-5 on cardiometabolic parameters in 453 nondiabetic Korean adults. In addition, we evaluated the impact of a 3-month combined exercise program on CTRP-3 and CTRP-5 levels in 76 obese women. The exercise program consisted of 45 min of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (300 kcal/session) and 20 min of resistance training (100 kcal/session) five times per week.
Both CTRP-3 and CTRP-5 concentrations were significantly higher in women (P<0.001) than in men (P=0.030). In a multiple stepwise regression analysis, CTRP-3 levels were independently associated with age, sex, and triglyceride, LDL cholesterol, adiponectin, and retinol-binding protein 4 (RBP4) levels (R2=0.182). After 3 months of a combined exercise program, cardiometabolic risk factors, including components of metabolic syndrome, insulin resistance, and RBP4 levels, decreased significantly. In particular, CTRP-3 levels decreased significantly (median [interquartile range] 444.3 [373.8-535.0] to 374.4 [297.2-435.9], P<0.001), whereas CTRP-5 levels were slightly increased (34.1 [28.6-44.3] to 38.4 [29.8-55.1], P=0.048).
A 3-month combined exercise program significantly decreased CTRP-3 levels and modestly increased CTRP-5 levels in obese Korean women.
使用新开发的 ELISA 检测联合运动方案对 C1q/肿瘤坏死因子相关蛋白 (CTRP)3 和 CTRP-5 水平以及新提出的与代谢和炎症相关的脂联素类似物的影响，并评估其在非糖尿病韩国成年人中的代谢和炎症相关关系以及与心血管代谢危险因素的相关性，同时探讨性别差异。
本横断面研究探讨了 CTRP-3 和 CTRP-5 对 453 名非糖尿病韩国成年人心血管代谢参数的影响。此外，我们还评估了 3 个月联合运动方案对 76 名肥胖女性 CTRP-3 和 CTRP-5 水平的影响。运动方案包括 45 分钟 60-75%年龄预测最大心率（300 卡路里/节）的有氧运动和 20 分钟 100 卡路里/节的阻力训练（每周 5 次）。
女性的 CTRP-3 和 CTRP-5 浓度均明显高于男性（P<0.001）（P=0.030）。在多元逐步回归分析中，CTRP-3 水平与年龄、性别以及甘油三酯、LDL 胆固醇、脂联素和视黄醇结合蛋白 4（RBP4）水平独立相关（R2=0.182）。经过 3 个月的联合运动方案后，包括代谢综合征成分、胰岛素抵抗和 RBP4 水平在内的心血管代谢危险因素显著降低。特别是，CTRP-3 水平显著降低（中位数[四分位数范围]444.3[373.8-535.0]至 374.4[297.2-435.9]，P<0.001），而 CTRP-5 水平略有升高（34.1[28.6-44.3]至 38.4[29.8-55.1]，P=0.048）。
3 个月的联合运动方案可显著降低肥胖韩国女性的 CTRP-3 水平，并适度升高 CTRP-5 水平。
