Hasegawa Natsuki, Fujie Shumpei, Horii Naoki, Uchida Masataka, Kurihara Toshiyuki, Sanada Kiyoshi, Hamaoka Takafumi, Iemitsu Motoyuki
Faculty of Sport and Health Science, Ritsumeikan University , Shiga , Japan.
Japan Society for the Promotion of Science , Tokyo , Japan.
Am J Physiol Regul Integr Comp Physiol. 2018 Jan 1;314(1):R94-R101. doi: 10.1152/ajpregu.00212.2017. Epub 2017 Oct 25.
Adiponectin regulates endothelial nitric oxide synthase in endothelial cells, and body fat loss by aerobic exercise training promotes adiponectin secretion. Recently, C1q/tumor necrosis factor-related proteins (CTRPs) have been identified as novel adipokines and are paralogs of adiponectin, but the association between exercise training-induced reduction of arterial stiffness and circulating CTRPs levels remains unclear. This study aimed to clarify whether the reduction of arterial stiffness in middle-aged and older adults is associated with the change in serum levels of CTRPs induced by exercise training. A total of 52 middle-aged and older participants were randomly divided into two groups: a training group ( n = 26) and a sedentary control group ( n = 26). Participants in the training group completed 8 wk of aerobic exercise training (60-70% peak oxygen uptake for 45 min, 3 days/wk). The reduction of percent whole body fat, abdominal visceral fat area, and carotid-femoral pulse-wave velocity (cfPWV) was significantly greater in the training group than in the control group ( P < 0.05). Moreover, the increase in serum adiponectin, CTRP3, and CTRP5 from baseline to 8 wk was significantly higher in the training group compared with the control group ( P < 0.05). Additionally, the training-induced change in cfPWV was negatively correlated with the training-induced change in serum adiponectin, CTRP3, and CTRP5 levels ( r = -0.51, r = -0.48, r = -0.42, respectively, P < 0.05), and increased plasma nitrite/nitrate level by exercise training was correlated only with adiponectin levels ( r = 0.41, P < 0.05). These results suggest that the exercise training-induced increase in serum CTRPs levels may be associated with the reduction of arterial stiffness in middle-aged and older adults.
脂联素可调节内皮细胞中的内皮型一氧化氮合酶，且有氧运动训练导致的体脂减少会促进脂联素分泌。最近，C1q/肿瘤坏死因子相关蛋白（CTRPs）已被鉴定为新型脂肪因子，是脂联素的旁系同源物，但运动训练引起的动脉僵硬度降低与循环CTRPs水平之间的关联仍不清楚。本研究旨在阐明中老年人群动脉僵硬度的降低是否与运动训练引起的血清CTRPs水平变化有关。共有52名中老年参与者被随机分为两组：训练组（n = 26）和久坐对照组（n = 26）。训练组的参与者完成了8周的有氧运动训练（峰值摄氧量的60 - 70%，持续45分钟，每周3天）。训练组全身脂肪百分比、腹部内脏脂肪面积和颈股脉搏波速度（cfPWV）的降低幅度显著大于对照组（P < 0.05）。此外，与对照组相比，训练组从基线到8周时血清脂联素、CTRP3和CTRP5的增加幅度显著更高（P < 0.05）。另外，训练引起的cfPWV变化与训练引起的血清脂联素、CTRP3和CTRP5水平变化呈负相关（分别为r = -0.51、r = -0.48、r = -0.42，P < 0.05），且运动训练引起的血浆亚硝酸盐/硝酸盐水平升高仅与脂联素水平相关（r = 0.41，P < 0.05）。这些结果表明，运动训练引起的血清CTRPs水平升高可能与中老年人群动脉僵硬度的降低有关。
