Shahiddoust Fatemeh, Monazzami Amir Abbas
Department of Sport Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
BMC Sports Sci Med Rehabil. 2025 Apr 8;17(1):73. doi: 10.1186/s13102-025-01123-4.
Obesity, defined as excessive body fat accumulation, is closely linked to an increased risk of metabolic disorders, cardiovascular diseases, and insulin resistance. This study investigates the effects of combined training (CT) and high-intensity interval training (HIIT) on insulin sensitivity, atherogenic index of plasma (AIP), and serum levels of C1q/TNF-related proteins (CTRP1 and CTRP3) in overweight and obese women.
Thirty-three overweight and obese women (aged 18-50 years) were randomly divided into three groups: control (CON, n = 10), HIIT(n = 9), and combined training (CT, n = 10). The HIIT protocol consisted of intervals performed at 100% of maximum aerobic velocity (MAV) and rest intervals at 50% of MAV, with a 30-s work-to-rest ratio. The CT sessions included RT followed by AT. RT comprised seven exercises performed in three sets of 10-16 repetitions at 60-75% of one-repetition maximum (1RM). AT involved running for 15-30 min at 60-75% of heart rate reserve. Subjects trained three times per week. Body composition, biochemical, and functional assessments were conducted 48 h before and after the interventions.
Body mass index 1.3% and 2% (p = 0.001); TG 1.7%, 1.2% (p = 0.001);LDL 0.93%,0.83% (p = 0.012); HOMA-IR 9.5%,11.7% (p = 0.018); AST 4.2%,11.7% (p = 0.001); ALT 9.3%,10.9% (p = 0.001); 1RM 2.5%, 14.2% (p = 0.001); and maximum oxygen consumption 8%,2.4% (p = 0.001) showed significant improvements in both the HIIT and CT groups,resectively. Additionally, serum levels of CTRP 10.47%,0.34% (p = 0.007); and CTRP3 1.51%,1.53% (p = 0.011) significantly decreased in the HIIT and CT groups,resectively.
The results suggest that HIIT and CT are effective strategies for improving body composition, lipid profile, glycemic control, liver enzyme levels, and functional capacity. Moreover, both exercise modalities were associated with reduced serum levels of the adipokines CTRP1 and CTRP3, highlighting a potential link between these biomarkers and improvements in body composition, lipid profile, glycemic control, and liver enzyme levels.
Registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20241207063967 N1) on 18/01/2025. Access at https:// https://irct.behdasht.gov.ir/trial/80615 .
肥胖被定义为体内脂肪过度堆积，与代谢紊乱、心血管疾病和胰岛素抵抗风险增加密切相关。本研究调查了联合训练（CT）和高强度间歇训练（HIIT）对超重和肥胖女性胰岛素敏感性、血浆致动脉粥样硬化指数（AIP）以及C1q/TNF相关蛋白（CTRP1和CTRP3）血清水平的影响。
33名超重和肥胖女性（年龄18 - 50岁）被随机分为三组：对照组（CON，n = 10）、HIIT组（n = 9）和联合训练组（CT，n = 10）。HIIT方案包括以最大有氧速度（MAV）的100%进行间歇训练，以MAV的50%进行休息间歇，工作与休息比例为30秒。CT课程包括抗阻训练（RT） followed by有氧训练（AT）。RT包括七项练习，每组进行10 - 16次重复，共三组，强度为一次重复最大值（1RM）的60 - 75%。AT包括以心率储备的60 - 75%进行15 - 30分钟的跑步。受试者每周训练三次。在干预前后48小时进行身体成分、生化和功能评估。
体重指数在HIIT组和CT组分别显著改善了1.3%和2%（p = 0.001）；甘油三酯分别降低1.7%、1.2%（p = 0.001）；低密度脂蛋白分别降低0.93%、0.83%（p = 0.012）；胰岛素抵抗指数分别降低9.5%、11.7%（p = 0.0l8）；谷草转氨酶分别降低4.2%、11.7%（p = 0.001）；谷丙转氨酶分别降低9.3%、10.9%（p = 0.001）；1RM分别提高2.5%、14.2%（p = 0.001）；最大摄氧量分别提高8%、2.4%（p = 0.001）。此外，HIIT组和CT组血清CTRP水平分别显著降低10.47%、0.34%（p = 0.007）；CTRP3水平分别降低1.51%、1.53%（p = 0.011）。
结果表明，HIIT和CT是改善身体成分、血脂谱、血糖控制、肝酶水平和功能能力的有效策略。此外，两种运动方式均与脂肪因子CTRP1和CTRP3血清水平降低有关，突出了这些生物标志物与身体成分、血脂谱、血糖控制和肝酶水平改善之间的潜在联系。
于2025年1月18日在伊朗临床试验注册中心（IRCT20241207063967 N1）进行回顾性注册。可在https://https://irct.behdasht.gov.ir/trial/80615访问。
