Departments of Psychiatry and Psychology, Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA.
Nat Rev Neurosci. 2013 Jul;14(7):488-501. doi: 10.1038/nrn3524.
Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its negative impact and thus results in anxiety. Here, we focus the broad literature on the neurobiology of anxiety through the lens of uncertainty. We identify five processes that are essential for adaptive anticipatory responses to future threat uncertainty and propose that alterations in the neural instantiation of these processes result in maladaptive responses to uncertainty in pathological anxiety. This framework has the potential to advance the classification, diagnosis and treatment of clinical anxiety.
对未来威胁的不确定性会破坏我们避免威胁或减轻其负面影响的能力，从而导致焦虑。在这里，我们通过不确定性的视角聚焦于焦虑的神经生物学的广泛文献。我们确定了五个对于未来威胁不确定性的适应性预期反应至关重要的过程，并提出这些过程的神经表现的改变导致了病理性焦虑对不确定性的适应不良反应。这个框架有可能推进临床焦虑的分类、诊断和治疗。
