Ruhno J, Howie K, Anderson M, Andersson B, Vanzieleghem M, Hitch D, Lapp P, Denburg J, Dolovich J
Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Allergy. 1990 Jul;45(5):370-4. doi: 10.1111/j.1398-9995.1990.tb00513.x.
Respiratory epithelial mast cells are an expression of airway inflammatory processes. Nasal epithelial mast cells are known to be increased in allergic rhinitis and have now been examined in patients with nasal polyps. Metachromatic cell counts (mean +/- standard error) expressed as the sum of large mast cells, atypical mast cells and basophils in epithelial scrapings of the inferior turbinates, assessed after Carnoy's fixation and toluidine blue staining (pH 0.5), were 37.5 +/- 29 in non-allergic normal control subjects (n = 11), 435 +/- 130 in polyp patients who were allergic (n = 18), and 699 +/- 267 in polyp patients who were not allergic (n = 8). Metachromatic cell counts in epithelial scrapings obtained in vivo from nasal polyps of allergic patients (n = 8) were 1769 +/- 962, and 2308 +/- 1544 from polyps of non-allergic patients (n = 5); metachromatic counts were 2089 +/- 633 in epithelial scrapings from excised polyps of allergic patients (n = 14) and 2214 +/- 640 from polyps of non-allergic patients (n = 13). It is concluded that the number of metachromatic cells in the epithelium of nasal polyps and the adjacent nasal mucosa is elevated compared with normal nasal epithelium and the increased number does not depend upon allergy.
呼吸道上皮肥大细胞是气道炎症过程的一种表现。已知鼻上皮肥大细胞在过敏性鼻炎中会增多，目前已对鼻息肉患者进行了相关检查。在经卡诺固定液固定和甲苯胺蓝染色（pH 0.5）后，对下鼻甲上皮刮片进行评估，以异染性细胞计数（均值±标准误）表示，即大肥大细胞、非典型肥大细胞和嗜碱性粒细胞的总和，在非过敏性正常对照受试者（n = 11）中为37.5±29，在过敏性息肉患者（n = 18）中为435±130，在非过敏性息肉患者（n = 8）中为699±267。从过敏性患者鼻息肉（n = 8）体内获取的上皮刮片中异染性细胞计数为1769±962，从非过敏性患者鼻息肉（n = 5）中获取的为2308±1544；从过敏性患者切除的息肉（n = 14）上皮刮片中异染性计数为2089±633，从非过敏性患者息肉（n = 13）中获取的为2214±640。得出的结论是，与正常鼻上皮相比，鼻息肉及其相邻鼻黏膜上皮中的异染性细胞数量增加，且增加的数量不取决于过敏情况。
