Drake-Lee A B, Chevreton E, Lowe D
Institute of Laryngology and Otology, London.
J Laryngol Otol. 1988 Dec;102(12):1099-101. doi: 10.1017/s0022215100107431.
Mast cells in rats have been categorized into mucosal and connective tissue mast cells by properties which include their fixation characteristics and their distribution in tissues. There are a number of factors which make this classification unsatisfactory including the variability of fixation, intensity of background staining and the application of animal studies to man. Seasonal allergic reactions in the nose of man occur both in the surface metachromatic cells and in those within the epithelium; the latter are presumed to be mucosal mast cells. The aim of this study was to look at the distribution and the fixation characteristics of mast cells in inferior turbinates and nasal polyps. Both techniques show that cells are more abundant in the submucosa and the fact that Carnoy's fixative shows them better and this may be due to the lack of intensity in the background staining. There is no evidence that mast cells are more frequent in the epithelium. These findings would suggest the nasal polyps are not an allergic disease.
大鼠体内的肥大细胞已根据其固定特性和在组织中的分布等特性，被分为黏膜肥大细胞和结缔组织肥大细胞。有许多因素使得这种分类并不令人满意，包括固定的可变性、背景染色强度以及将动物研究应用于人类。人类鼻腔的季节性过敏反应发生在表面异染性细胞以及上皮内的细胞中；后者被推测为黏膜肥大细胞。本研究的目的是观察下鼻甲和鼻息肉中肥大细胞的分布及固定特性。两种技术均显示黏膜下层的细胞更为丰富，且卡诺固定液能更好地显示这些细胞，这可能是由于背景染色强度较低。没有证据表明上皮中的肥大细胞更为常见。这些发现表明鼻息肉并非过敏性疾病。
