[巴西人群中HLA与重症肌无力的相关性]

[Correlation of HLA and myasthenia gravis in a Brazilian population].

作者信息

Dias-Tosta E, Morato-Fernandez R N, Villaça J A

机构信息

Hospital Docente Assistencial de Brasília, Brasil.

出版信息

Arq Neuropsiquiatr. 1990 Mar;48(1):49-54. doi: 10.1590/s0004-282x1990000100008.

DOI:10.1590/s0004-282x1990000100008

PMID:2378575

Abstract

Based on the fact that Brazilian ethnic groups are mixed and therefore different from caucasian, chinese or japanese populations the authors studied the HLA antigen distribution in 37 myasthenic patients. The control group consisted of 69 healthy individuals of the same population studied in the same laboratory. The antigens HLA B8 showed the highest relative risk for female, younger than 40 years old, with thymic hyperplasia. Also the HLA B8 and A1 showed high frequency for black myasthenic patients.

摘要

基于巴西族群混合，因而不同于高加索人、中国人或日本人种这一事实，作者研究了37例重症肌无力患者的HLA抗原分布情况。对照组由在同一实验室研究的69名同一种族的健康个体组成。抗原HLA B8在40岁以下、患有胸腺增生的女性中显示出最高的相对风险。此外，HLA B8和A1在黑人重症肌无力患者中出现的频率较高。