重症肌无力男性患者的HLA - A、- B、- C和 - D抗原

HLA-A, -B, -C and -D antigens in male patients with myasthenia gravis.

作者信息

Säfwenberg J, Hammarström L, Lindblom J B, Matell G, Möller E, Osterman P O, Smith C I

出版信息

Tissue Antigens. 1978 Aug;12(2):136-42. doi: 10.1111/j.1399-0039.1978.tb01309.x.

DOI:10.1111/j.1399-0039.1978.tb01309.x

Abstract

HLA-A, -B, -C and -D antigens were determined in 54 male Myasthenia Gravis patients. A significant increase of the B8 antigen frequency was found among patients with an onset of the disease before the age of 35. No significant increase was found among the D antigens. In a combined male and female material with an early age at onset, thymic hyperplasia was correlated to the presence of HLA-B8.

摘要

对54例男性重症肌无力患者进行了HLA - A、- B、- C和 - D抗原检测。发现35岁以前发病的患者中B8抗原频率显著增加。在D抗原中未发现显著增加。在发病年龄早的男性和女性混合样本中，胸腺增生与HLA - B8的存在相关。