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Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121.

作者信息

Hudson Sean A, Surade Sachin, Coyne Anthony G, McLean Kirsty J, Leys David, Munro Andrew W, Abell Chris

机构信息

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

出版信息

ChemMedChem. 2013 Sep;8(9):1451-6. doi: 10.1002/cmdc.201300219. Epub 2013 Jun 20.

DOI:10.1002/cmdc.201300219
PMID:23788280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4281926/
Abstract
摘要

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Biochemistry. 2012 Jul 24;51(29):5822-30. doi: 10.1021/bi300551b. Epub 2012 Jul 12.
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Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors.结构-活性关系和作用机制研究强调 1-(4-联苯甲基)-1H-咪唑衍生的小分子作为有效的 CYP121 抑制剂。
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J Fungi (Basel). 2021 Jan 20;7(2):67. doi: 10.3390/jof7020067.
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J Am Chem Soc. 2010 Feb 17;132(6):1758-9. doi: 10.1021/ja909690a.
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