解析心脏中良好与不良信号通路：钙调神经磷酸酶-活化 T 细胞核因子的作用。
Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells.
机构信息
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Howard Hughes Medical Institute, Cincinnati, OH 45229, USA.
出版信息
Circ Res. 2013 Jun 21;113(1):16-9. doi: 10.1161/CIRCRESAHA.113.301667.
Abstract
Nine years ago, we published an article that suggested a specialized role for calcineurin–nuclear factor of activated T-cells (NFAT) signaling in regulating pathological cardiac hypertrophy preferentially over physiological growth and, in fact, the later response was associated with reduced calcineurin-NFAT activity. Since this time we and others have continued to uncover how this signaling effector pathway functions in the heart in regulating specific aspects of the growth response during disease and with exercise.
摘要
九年前，我们发表了一篇文章，提出钙调神经磷酸酶-激活 T 细胞的核因子（NFAT）信号在调节病理性心肌肥厚方面具有特殊作用，而这种作用优先于生理性生长，事实上，后者的反应与钙调神经磷酸酶-NFAT 活性的降低有关。从那时起，我们和其他人一直在探索这种信号效应途径在心脏中的功能，以及它如何在疾病和运动过程中调节生长反应的特定方面。
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Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells.解析心脏中良好与不良信号通路：钙调神经磷酸酶-活化 T 细胞核因子的作用。
Circ Res. 2013 Jun 21;113(1):16-9. doi: 10.1161/CIRCRESAHA.113.301667.
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Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.硫酸乙酰肝素蛋白聚糖-4 对于离心性心肌肥厚的发生发展是必需的，这是通过牵张诱导的钙调神经磷酸酶-NFAT 通路的激活实现的。
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