Department of Psychology, Second University of Naples, Caserta, Italy; IDC Hermitage-Capodimonte, Naples, Italy.
Eur J Neurol. 2014 Mar;21(3):541-4. doi: 10.1111/ene.12219. Epub 2013 Jun 21.
Subthreshold depression (SubD) is characterized by clinically relevant depressive symptoms not meeting criteria for major depression. The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demented Parkinson's disease (PD) outpatients.
Amongst 115 patients, SubD was identified in 30 patients, major depression in 33; 36 patients were classified as non-depressed. Enrolled patients were administered tests and questionnaires validated in PD for assessing objective and subjective cognitive dysfunctions.
On objective cognitive measures SubD patients did not differ from non-depressed patients, whereas depressed patients achieved significantly lower scores than the other two groups. SubD and depressed patients reported more cognitive complaints than non-depressed patients.
SubD is a non-motor aspect of PD that is not related to objective cognitive deficits but is associated with subjective cognitive complaints, thus impacting on patients' well-being.
阈下抑郁（SubD）的特征是具有临床相关的抑郁症状，但不符合重度抑郁症的标准。本研究旨在调查阈下抑郁与主观认知主诉和/或客观认知障碍在连续非痴呆帕金森病（PD）门诊患者中的可能相关性。
在 115 名患者中，30 名患者被诊断为阈下抑郁，33 名患者被诊断为重度抑郁；36 名患者被归类为非抑郁。入组患者接受了用于评估 PD 患者客观和主观认知功能障碍的测试和问卷。
在客观认知测试中，阈下抑郁患者与非抑郁患者没有差异，而抑郁患者的得分明显低于其他两组。阈下抑郁和抑郁患者比非抑郁患者报告了更多的认知主诉。
阈下抑郁是 PD 的一种非运动方面，它与客观认知缺陷无关，但与主观认知主诉相关，从而影响患者的幸福感。
