Mei Zhaojun, Hu Hong, Zou Yi, Li Dandan
Luzhou Maternal and Child Health Hospital (Luzhou Second People's Hospital), Luzhou, Sichuan, China.
Department of Gynaecology, Luzhou Maternal and Child Health Hospital (Luzhou Second People's Hospital), Luzhou, Sichuan, China.
Front Physiol. 2023 Jun 12;14:1211896. doi: 10.3389/fphys.2023.1211896. eCollection 2023.
Vitamin D (VD) is known to play an important role in the maintenance of calcium homeostasis and bone metabolism. In recent years, there has also been a growing interest in Vitamin D for health issues beyond the bones. Menopausal women are at risk of reduced bone density and increased risk of fracture due to a decline in estrogen levels. There is also an increased risk of cardiovascular disease, diabetes and hyperlipidaemia due to impaired lipid metabolism. The menopausal and emotional symptoms due to menopause are also increasingly prominent. This article summarizes the role of Vitamin D in menopausal women's health, including the effects of Vitamin D on skeletal muscle, cardiovascular disease, Genitourinary Syndrome of Menopause (GSM), cancer and emotional symptoms. Vitamin D regulates the growth of vaginal epithelial cells and alleviates genitourinary tract problems in menopausal women. Vitamin D also modulates immune function and influences the production of adipokines. Vitamin D and its metabolites also have an anti-proliferative effect on tumour cells. This narrative review, by summarizing recent work on the role of Vitamin D in menopausal women and in animal models of menopause, aims to provide a basis for further development of the role of Vitamin D in the health of menopausal women.
维生素D（VD）在维持钙稳态和骨代谢中起着重要作用。近年来，人们对维生素D在骨骼以外的健康问题上的兴趣也与日俱增。绝经后女性由于雌激素水平下降，面临骨密度降低和骨折风险增加的问题。此外，由于脂质代谢受损，心血管疾病、糖尿病和高脂血症的风险也会增加。绝经引起的更年期症状和情绪症状也日益突出。本文总结了维生素D在绝经后女性健康中的作用，包括维生素D对骨骼肌、心血管疾病、更年期泌尿生殖综合征（GSM）、癌症和情绪症状的影响。维生素D调节阴道上皮细胞的生长，缓解绝经后女性的泌尿生殖系统问题。维生素D还能调节免疫功能并影响脂肪细胞因子的产生。维生素D及其代谢产物对肿瘤细胞也有抗增殖作用。这篇叙述性综述通过总结维生素D在绝经后女性和更年期动物模型中作用的最新研究成果，旨在为进一步研究维生素D在绝经后女性健康中的作用提供依据。
