Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Am J Pathol. 2013 Jul;183(1):3-9. doi: 10.1016/j.ajpath.2013.03.001.
Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis has been well characterized, new functions have been identified, including the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of mitochondrial metabolism, regulation of transcription factor signaling via a DNA-bound form, the induction of chromosomal instability, enhancement of DNA damage sensing and DNA damage repair, and feedback governing expression of the noncoding genome. This review describes the mechanisms of these new functions of cyclin D1.
细胞周期蛋白编码全酶的调节亚基，可磷酸化多种细胞底物。虽然细胞周期蛋白在细胞周期进程和肿瘤发生中的经典作用已得到很好的描述，但新的功能已被确定，包括诱导细胞迁移和侵袭、增强血管生成、抑制线粒体代谢、通过 DNA 结合形式调节转录因子信号、诱导染色体不稳定性、增强 DNA 损伤感应和 DNA 损伤修复，以及反馈调节非编码基因组的表达。本综述描述了细胞周期蛋白 D1 这些新功能的机制。
