Carobway Ltd., Nes Ziona 7406520, Israel.
Nutrients. 2022 Mar 30;14(7):1453. doi: 10.3390/nu14071453.
Carob is one of the major food trees for peoples of the Mediterranean basin, but it has also been traditionally used for medicinal purposes. Carob contains many nutrients and active natural products, and D-Pinitol is clearly one of the most important of these. D-Pinitol has been reported in dozens of scientific publications and its very diverse medicinal properties are still being studied. Presently, more than thirty medicinal activities of D-Pinitol have been reported. Among these, many publications have reported the strong activities of D-Pinitol as a natural antidiabetic and insulin regulator, but also as an active anti-Alzheimer, anticancer, antioxidant, and anti-inflammatory, and is also immune- and hepato-protective. In this review, we will present a brief introduction of the nutritional and medicinal importance of Carob, both traditionally and as found by modern research. In the introduction, we will present Carob's major active natural products. The structures of inositols will be presented with a brief literature summary of their medicinal activities, with special attention to those inositols in Carob, as well as D-Pinitol's chemical structure and its medicinal and other properties. D-Pinitol antidiabetic and insulin regulation activities will be extensively presented, including its proposed mechanism of action. Finally, a discussion followed by the conclusions and future vision will summarize this article.
角豆是地中海地区人民的主要食物树之一，但它也一直被传统上用于药用目的。角豆含有许多营养物质和活性天然产物，而 D-松醇显然是其中最重要的一种。D-松醇已在数十篇科学出版物中报道，其非常多样化的药用特性仍在研究中。目前，已经报道了 D-松醇超过三十种的药用活性。其中，许多出版物报道了 D-松醇作为天然抗糖尿病和胰岛素调节剂的强大活性，但也具有抗老年痴呆症、抗癌、抗氧化和抗炎作用，并且还具有免疫和保肝作用。在这篇综述中，我们将简要介绍角豆的营养和药用重要性，包括传统和现代研究的发现。在引言中，我们将介绍角豆的主要活性天然产物。将介绍肌醇的结构，并简要总结其药用活性，特别注意角豆中的肌醇以及 D-松醇的化学结构及其药用和其他性质。将广泛介绍 D-松醇的抗糖尿病和胰岛素调节活性，包括其作用机制的建议。最后，将通过讨论和未来展望来总结这篇文章。
