Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Neurology, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
J Pain. 2013 Dec;14(12):1553-63. doi: 10.1016/j.jpain.2013.04.009. Epub 2013 Jun 21.
To quantitatively assess cortical dysfunction in pediatric migraine, 31 adolescents with acute migraine and age- and gender-matched controls were studied using a magnetoencephalography (MEG) system at a sampling rate of 6,000 Hz. Neuromagnetic brain activation was elicited by a finger-tapping task. The spectral and spatial signatures of magnetoencephalography data in 5 to 2,884 Hz were analyzed using Morlet wavelet and beamformers. Compared with controls, 31 migraine subjects during their headache attack phases (ictal) showed significantly prolonged latencies of neuromagnetic activation in 5 to 30 Hz, increased spectral power in 100 to 200 Hz, and a higher likelihood of neuromagnetic activation in the supplementary motor area, the occipital and ipsilateral sensorimotor cortices, in 2,200 to 2,800 Hz. Of the 31 migraine subjects, 16 migraine subjects during their headache-free phases (interictal) showed that there were no significant differences between interictal and control MEG data except that interictal spectral power in 100 to 200 Hz was significantly decreased. The results demonstrated that migraine subjects had significantly aberrant ictal brain activation, which can normalize interictally. The spread of abnormal ictal brain activation in both low- and high-frequency ranges triggered by movements may play a key role in the cascade of migraine attacks.
This is the first study focusing on the spectral and spatial signatures of cortical dysfunction in adolescents with migraine using MEG signals in a frequency range of 5 to 2,884 Hz. This methodology analyzing aberrant brain activation may be important for developing new therapeutic interventions for migraine in the future.
使用 6000 Hz 的采样率，通过脑磁图（MEG）系统对 31 例急性偏头痛青少年患者和年龄及性别匹配的对照组进行研究，以定量评估儿科偏头痛患者的皮质功能障碍。通过手指敲击任务诱发神经磁激活。使用 Morlet 小波和波束形成器分析 5 至 2884 Hz 的脑磁图数据的频谱和空间特征。与对照组相比，31 例偏头痛患者在头痛发作期（发作期）的神经磁激活潜伏期明显延长，5 至 30 Hz 的频谱功率增加，2200 至 2800 Hz 的运动前区、枕叶和同侧感觉运动皮质的神经磁激活可能性更高。在 31 例偏头痛患者中，16 例偏头痛患者在头痛缓解期（发作间期）的发作间期和对照组的 MEG 数据之间无显著差异，除了 100 至 200 Hz 的发作间期频谱功率显著降低。结果表明，偏头痛患者的发作期大脑激活明显异常，这种异常可在发作间期恢复正常。运动诱发的低频和高频范围内异常发作期大脑激活的扩散可能在偏头痛发作的级联反应中起关键作用。
这是第一项使用 5 至 2884 Hz 频率范围内的 MEG 信号研究青少年偏头痛患者皮质功能障碍的频谱和空间特征的研究。这种分析异常脑激活的方法对于未来开发偏头痛的新治疗干预措施可能很重要。
