AP-HP, Jean Verdier hospital, Reproductive Biology unit-CECOS, Bondy, France.
Asian J Androl. 2013 Sep;15(5):622-5. doi: 10.1038/aja.2013.65. Epub 2013 Jun 24.
There has been a growing interest over the past few years in the impact of male nutrition on fertility. Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index (BMI). A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling (TUNEL) assay, we observed an increased rate of sperm DNA damage in obese men (odds ratio (95% confidence interval): 2.5 (1.2-5.1)).
在过去的几年中，人们对男性营养对生育能力的影响越来越感兴趣。不孕与男性超重或肥胖有关，而且在体重指数（BMI）较高的情况下，常规精液参数值似乎发生了改变。已经发表了一些评估 BMI 对精子 DNA 完整性影响的研究，但它们并没有达成强烈共识。我们的目的是通过一项为期 3 年的多中心研究进一步探讨精子 DNA 完整性与 BMI 之间的关系。纳入了 330 对不育夫妇中的男性伴侣。通过末端尿嘧啶核苷尼克末端标记（TUNEL）检测，我们观察到肥胖男性精子 DNA 损伤的发生率增加（比值比（95%置信区间）：2.5（1.2-5.1））。
