来自中药灵芝的新型三萜类化合物。

New triterpenes from a Chinese medicine, goreishi.

作者信息

Numata A, Takahashi C, Miyamoto T, Yoneda M, Yang P M

机构信息

Osaka University of Pharmaceutical Sciences, Matsubara, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Apr;38(4):942-4. doi: 10.1248/cpb.38.942.

DOI:10.1248/cpb.38.942

PMID:2379288

Abstract

Besides serratagenic acid, three new ursane-type triterpenes, named goreishic acids I (1), II (2), and III (3), were isolated from a Chinese medicine, Goreishi (the feces of Trogopterus xanthipes Milne-Edwards). The structures of 1, 2 and 3 were respectively determined as 2 alpha,3 beta-dihydroxyursa-12,18-dien-28-oic acid, 2 alpha,3 beta-dihydroxy-23-norursa-12,18-dien-28-oic acid and 2 alpha,3 beta-dihydroxy-24-norursa-12,18-dien-28-oic acid on the basis of spectroscopic evidence.

摘要

除了锯齿酸之外，还从一味中药五灵脂（复齿鼯鼠Trogopterus xanthipes Milne-Edwards的粪便）中分离出三种新的乌苏烷型三萜，命名为戈雷希酸I（1）、II（2）和III（3）。基于光谱证据，分别将1、2和3的结构确定为2α，3β-二羟基乌苏-12,18-二烯-28-酸、2α，3β-二羟基-23-降乌苏-12,18-二烯-28-酸和2α，3β-二羟基-24-降乌苏-12,18-二烯-28-酸。