Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Molecules. 2013 Jun 21;18(6):7323-35. doi: 10.3390/molecules18067323.
Epimedium sagittatum (Sieb. et Zucc.) Maxim is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction in Western Medicine. This study evaluates the herbal-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil in rats by ultra-performance liquid chromatography. The rat plasma was sampled from each anesthetized rat after pretreatment with 3-days Epimedium sagittatum extract (1/2 g/kg/day) and intravenous injection with sildenafil (10/30 mg/kg). The pharmacokinetic data demonstrate that the area under the concentration-time curve (AUC) of sildenafil (10 mg/kg) was significantly decreased in groups that received a high dose of Epimedium sagittatum extract. In conclusion, the study demonstrates that there was significant herb-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil at low and high daily doses, suggesting co-administration use of Epimedium sagittatum extract and sildenafil in clinical practice should be prevented due to possible herb-drug interactions.
朝蓟（Sieb. et Zucc.） Maxim 是一种用于治疗中医勃起功能障碍的草药。西地那非是一种磷酸二酯酶 5 抑制剂，用于治疗西医勃起功能障碍。本研究通过超高效液相色谱法评估朝蓟提取物对西地那非在大鼠体内药代动力学的草药-药物相互作用。在给予朝蓟提取物（1/2 g/kg/天）预处理 3 天后，从每只麻醉大鼠中抽取大鼠血浆，并静脉注射西地那非（10/30 mg/kg）。药代动力学数据表明，接受高剂量朝蓟提取物的组中，西地那非（10 mg/kg）的浓度-时间曲线下面积（AUC）显著降低。总之，该研究表明，低剂量和高剂量的朝蓟提取物对西地那非的药代动力学有显著的草药-药物相互作用，提示在临床实践中应避免同时使用朝蓟提取物和西地那非，因为可能存在草药-药物相互作用。
