Lee Sang Ju, Kang Jin Moon, Chung Won Soon, Kim Young Koo, Kim Hei Sung
Yeonsei Star Skin and Laser Clinic, Seoul, South Korea.
Lasers Med Sci. 2014 Mar;29(2):615-9. doi: 10.1007/s10103-013-1372-8. Epub 2013 Jun 21.
Atrophic facial scars which commonly occur after inflammatory acne vulgaris can be extremely disturbing to patients both physically and psychologically. Treatment with fractional laser devices has become increasingly popular, but there has been disappointment in terms of effectiveness. The objective of this study was to assess the safety and efficacy of ablative full-face resurfacing on atrophic acne scars in the Korean population. A total of 22 patients, aged 25-44 years, underwent a new modality of resurfacing combining both short-pulsed and dual-mode erbium:yttrium-aluminum garnet (Er:YAG) laser. The patients had Fitzpatrick skin types ranging from III to V. Photographs were taken before and up to 6 months after treatment. Results were evaluated for the degree of clinical improvement and any adverse events. Degree of improvement was graded using a four-point scale: poor (1) = <25%, fair (2) = 25-50%, good (3) = 51-75%, and excellent (4) = >75%. Based on the blinded photo assessments by two independent reviewers, clinically and statistically significant mean improvement of 3.41 was observed (one-sample Wilcoxon signed rank test, P < 0.001). Complete wound healing occurred between 6 and 9 days. Erythema occurred in all patients and lasted longer than 3 months in two patients (9.1%). Postinflammatory hyperpigmentation occurred in ten patients (45.5%) and lasted longer than 3 months in one patient (4.5%). One patient experienced mild hypopigmentation (4.5%). Mild to moderate acne flare-up occurred in five patients (22.7%). No other adverse effects were observed. A new modality of Er:YAG laser resurfacing combining short-pulsed and dual-mode Er:YAG laser is a safe and very effective treatment modality for atrophic facial acne scars in Asians with darker skin tones.
萎缩性面部瘢痕常见于寻常性炎性痤疮之后,会在生理和心理上给患者带来极大困扰。使用分次激光设备进行治疗越来越普遍,但在有效性方面却不尽如人意。本研究的目的是评估剥脱性全脸皮肤磨削术治疗韩国人群萎缩性痤疮瘢痕的安全性和有效性。共有22例年龄在25至44岁之间的患者接受了一种新的皮肤磨削术式,该术式结合了短脉冲和双模式铒:钇铝石榴石(Er:YAG)激光。患者的皮肤 Fitzpatrick 分型为Ⅲ至Ⅴ型。在治疗前及治疗后长达6个月内拍摄照片。对临床改善程度和任何不良事件进行评估。改善程度采用四点量表进行分级:差(1)=<25%,一般(2)=25 - 50%,好(3)=51 - 75%,优(4)=>75%。基于两名独立评估者的盲法照片评估,观察到临床和统计学上显著的平均改善为3.41(单样本 Wilcoxon 符号秩检验,P<0.001)。伤口完全愈合发生在6至9天之间。所有患者均出现红斑,两名患者(9.1%)红斑持续超过3个月。10例患者(45.5%)出现炎症后色素沉着,1例患者(4.5%)色素沉着持续超过3个月。1例患者出现轻度色素减退(4.5%)。5例患者(22.7%)出现轻度至中度痤疮爆发。未观察到其他不良反应。一种结合短脉冲和双模式 Er:YAG 激光的新型 Er:YAG 激光皮肤磨削术,对于肤色较深的亚洲人萎缩性面部痤疮瘢痕是一种安全且非常有效的治疗方式。