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用于特发性食管贲门失弛缓症的临时性内镜金属支架

Temporary endoscopic metallic stent for idiopathic esophageal achalasia.

作者信息

Coppola Franco, Gaia Silvia, Rolle Emanuela, Recchia Serafino

机构信息

1Department Gastroenterology, San Giovanni Bosco Hospital, Turin, Italy.

出版信息

Surg Innov. 2014 Feb;21(1):11-4. doi: 10.1177/1553350613492024. Epub 2013 Jun 21.

Abstract

Idiopathic achalasia is a motor disorder of the esophagus of unknown etiology caused by loss of motor neurons determining an altered motility. It may determine severe symptoms such as progressive dysphagia, regurgitations, and pulmonary aspirations. Many therapeutic options may be offered to patients with achalasia, from surgery to endoscopic treatments such as pneumatic dilation, botulinum injection, peroral endoscopic myotomy, or endoscopic stenting. Recently, temporary placement of a stent was proposed by Cheng as therapy for achalasia disorders, whereas no Western authors have dealt with it up to date. The present study reports our preliminary experience in 7 patients with achalasia treated with a temporary stent. Partially covered self-expanding metallic stents (Micro-Tech, Nanjin, China) 80 mm long and 30 mm wide were placed under fluoroscopic control and removed after 6 days. Clinical follow-up was scheduled to check endoscopic success, symptoms release, and complications. The placement and the removal of the stents were obtained in all patients without complications. Mean clinical follow-up was 19 months. Five out of 7 patients referred total symptoms release and 2 experienced significant improvement of dysphagia. The procedure was not time consuming and was safe; no mild or severe complications were registered. In conclusion, our results may suggest a possible safe and effective endoscopic alternative treatment in patients with achalasia; however, further larger studies are necessary to confirm these promising, but very preliminary, data.

摘要

特发性贲门失弛缓症是一种病因不明的食管运动障碍性疾病,由运动神经元丧失导致动力改变引起。它可能导致严重症状,如进行性吞咽困难、反流和肺误吸。对于贲门失弛缓症患者,有多种治疗选择,从手术到内镜治疗,如气囊扩张、肉毒杆菌注射、经口内镜下肌切开术或内镜支架置入术。最近,Cheng提出临时放置支架作为贲门失弛缓症的治疗方法,而目前尚无西方作者对此进行过研究。本研究报告了我们对7例贲门失弛缓症患者采用临时支架治疗的初步经验。在透视控制下放置80毫米长、30毫米宽的部分覆膜自膨式金属支架(中国南京微创医疗器械有限公司),6天后取出。安排临床随访以检查内镜治疗的成功率、症状缓解情况和并发症。所有患者均成功放置和取出支架,无并发症发生。平均临床随访时间为19个月。7例患者中有5例症状完全缓解,2例吞咽困难明显改善。该手术耗时短且安全;未记录到轻度或重度并发症。总之,我们的结果可能提示贲门失弛缓症患者有一种安全有效的内镜替代治疗方法;然而,需要进一步的大规模研究来证实这些有前景但非常初步的数据。

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