Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London, UK.
Mol Immunol. 2013 Dec 15;56(3):181-90. doi: 10.1016/j.molimm.2013.05.223. Epub 2013 Jun 22.
Complement receptors are expressed on cells of the innate and the adaptive immune system. They play important roles in pathogen and danger sensing as they translate the information gathered by complement fluid phase sensors into cellular responses. Further, they control complement activation on viable and apoptotic host cells, clearance of immune complexes and mediate opsonophagocytosis. More recently, evidence has accumulated that complement receptors form a complex network with other innate receptors systems such as the Toll-like receptors, the Notch signaling system, IgG Fc receptors and C-type lectin receptors contributing to the benefit and burden of innate and adaptive immune responses in autoimmune and allergic diseases as well as in cancer and transplantation. Here, we will discuss recent developments and emerging concepts of complement receptor activation and regulation with a particular focus on the differentiation, maintenance and contraction of effector and regulatory T cells.
补体受体表达于先天和适应性免疫系统的细胞上。它们在病原体和危险感知中发挥重要作用，因为它们将补体液相传感所收集的信息转化为细胞反应。此外，它们控制活的和凋亡的宿主细胞上的补体激活、免疫复合物的清除以及调理吞噬作用。最近的证据表明，补体受体与其他先天受体系统（如 Toll 样受体、Notch 信号系统、IgG Fc 受体和 C 型凝集素受体）形成一个复杂的网络，这有助于自身免疫和过敏性疾病以及癌症和移植中的先天和适应性免疫反应的获益和负担。在这里，我们将讨论补体受体激活和调节的最新进展和新兴概念，特别关注效应和调节性 T 细胞的分化、维持和收缩。
