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1
Daptomycin Activity against Methicillin-Resistant Staphylococcus aureus Is Enhanced by d-Cycloserine in a Mechanism Associated with a Decrease in Cell Surface Charge.在与细胞表面电荷减少相关的机制中，d-环丝氨酸可增强达托霉素对耐甲氧西林金黄色葡萄球菌的活性。
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2
Telavancin in therapy of experimental aortic valve endocarditis in rabbits due to daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus.替拉万星治疗兔实验性主动脉瓣心内膜炎的疗效，该模型由耐甲氧西林金黄色葡萄球菌（daptomycin 不敏感株）引起。
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Telavancin demonstrates activity against methicillin-resistant Staphylococcus aureus isolates with reduced susceptibility to vancomycin, daptomycin, and linezolid in broth microdilution MIC and one-compartment pharmacokinetic/pharmacodynamic models.在肉汤微量稀释法最小抑菌浓度（MIC）及一室药代动力学/药效学模型中，替拉万星对耐甲氧西林金黄色葡萄球菌分离株显示出活性，这些分离株对万古霉素、达托霉素和利奈唑胺的敏感性降低。
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Phenotypic and genotypic correlates of daptomycin-resistant methicillin-susceptible Staphylococcus aureus clinical isolates.达托霉素耐药的甲氧西林敏感金黄色葡萄球菌临床分离株的表型和基因型相关性
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Evaluation of ceftaroline activity versus daptomycin (DAP) against DAP-nonsusceptible methicillin-resistant Staphylococcus aureus strains in an in vitro pharmacokinetic/pharmacodynamic model.评估头孢洛林对体外药代动力学/药效学模型中达托霉素（DAP）不敏感的耐甲氧西林金黄色葡萄球菌（MRSA）菌株的活性。
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Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates.耐达霉素耐药性耐甲氧西林金黄色葡萄球菌（MRSA）临床分离株中，增加的细胞壁磷壁酸产生和 D-丙氨酸化是常见的表型。
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D-alanine synthesis and exogenous alanine affect the antimicrobial susceptibility of .D-丙氨酸合成及外源性丙氨酸影响……的抗菌敏感性。 （原文此处不完整，缺少具体受影响对象）
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FEMS Microbiol Lett. 2024 Jan 9;371. doi: 10.1093/femsle/fnae007.
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New Antimicrobials and New Therapy Strategies for Endocarditis: Weapons That Should Be Defended.感染性心内膜炎的新型抗菌药物及新治疗策略：需加以捍卫的武器
J Clin Med. 2023 Dec 14;12(24):7693. doi: 10.3390/jcm12247693.
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D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus.D-环丝氨酸可提高万古霉素对万古霉素高度耐药金黄色葡萄球菌的疗效。
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本文引用的文献

1
Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall.金黄色葡萄球菌中达托霉素耐药的机制：细胞膜和细胞壁的作用。
Ann N Y Acad Sci. 2013 Jan;1277(1):139-58. doi: 10.1111/j.1749-6632.2012.06819.x. Epub 2012 Dec 5.
2
High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis.高剂量达托霉素联合磷霉素治疗耐甲氧西林敏感和耐甲氧西林金黄色葡萄球菌心内膜炎安全有效。
Antimicrob Agents Chemother. 2012 Aug;56(8):4511-5. doi: 10.1128/AAC.06449-11. Epub 2012 May 29.
3
Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding.利用抗葡萄球菌β-内酰胺类药物提高达托霉素对耐甲氧西林金黄色葡萄球菌持续性菌血症的清除作用：增强达托霉素结合的作用。
Clin Infect Dis. 2011 Jul 15;53(2):158-63. doi: 10.1093/cid/cir340.
4
Daptomycin-oxacillin combinations in treatment of experimental endocarditis caused by daptomycin-nonsusceptible strains of methicillin-resistant Staphylococcus aureus with evolving oxacillin susceptibility (the "seesaw effect").达托霉素-苯唑西林联合治疗达托霉素中介耐甲氧西林金黄色葡萄球菌引起的实验性心内膜炎，伴有不断变化的苯唑西林敏感性（“跷跷板效应”）。
Antimicrob Agents Chemother. 2010 Aug;54(8):3161-9. doi: 10.1128/AAC.00487-10. Epub 2010 Jun 14.
5
Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌体外筛选的达托霉素耐药菌株的细胞膜特性分析
Antimicrob Agents Chemother. 2009 Jun;53(6):2312-8. doi: 10.1128/AAC.01682-08. Epub 2009 Mar 30.
6
Functional relationship between bacterial cell density and the efficacy of antibiotics.细菌细胞密度与抗生素疗效之间的功能关系。
J Antimicrob Chemother. 2009 Apr;63(4):745-57. doi: 10.1093/jac/dkn554. Epub 2009 Feb 13.
7
The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses.GraRS调控系统控制着金黄色葡萄球菌对抗菌宿主防御的敏感性。
BMC Microbiol. 2008 Jun 2;8:85. doi: 10.1186/1471-2180-8-85.
8
Daptomycin inoculum effects and mutant prevention concentration with Staphylococcus aureus.达托霉素对金黄色葡萄球菌的接种物效应及突变预防浓度
J Antimicrob Chemother. 2007 Dec;60(6):1380-3. doi: 10.1093/jac/dkm375. Epub 2007 Sep 28.
9
Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis.在耐甲氧西林金黄色葡萄球菌菌血症和骨髓炎治疗期间出现临床耐达托霉素金黄色葡萄球菌分离株。
J Clin Microbiol. 2006 Feb;44(2):595-7. doi: 10.1128/JCM.44.2.595-597.2006.
10
Evaluation of in vitro interaction of daptomycin with gentamicin or beta-lactam antibiotics against Staphylococcus aureus and Enterococci by FIC index and timed-kill curves.通过FIC指数和时间杀菌曲线评估达托霉素与庆大霉素或β-内酰胺类抗生素对金黄色葡萄球菌和肠球菌的体外相互作用。
J Chemother. 2005 Dec;17(6):614-21. doi: 10.1179/joc.2005.17.6.614.

在与细胞表面电荷减少相关的机制中，d-环丝氨酸可增强达托霉素对耐甲氧西林金黄色葡萄球菌的活性。

Daptomycin Activity against Methicillin-Resistant Staphylococcus aureus Is Enhanced by d-Cycloserine in a Mechanism Associated with a Decrease in Cell Surface Charge.

作者信息

Gasch O, Pillai S K, Dakos J, Miyakis S, Moellering R C, Eliopoulos G M

机构信息

Beth Israel Deaconess Medical Center

Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Antimicrob Agents Chemother. 2013 Sep;57(9):4537-4539. doi: 10.1128/AAC.00799-13. Epub 2013 Jun 24.

DOI:10.1128/AAC.00799-13
PMID:23796933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3754330/
Abstract

The killing activity of daptomycin against an isogenic pair of daptomycin-susceptible and daptomycin-nonsusceptible (DNS) methicillin-resistant (MRSA) strains was enhanced by the addition of certain cell wall agents at 1× MIC. However, when high inocula of the DNS strain were used, no significant killing was observed in our experiments. Cytochrome binding assays revealed d-cycloserine as the only agent associated with a reduction in the cell surface charge for both strains at the concentrations used.

摘要

在1×最小抑菌浓度（MIC）下添加某些细胞壁活性剂可增强达托霉素对一对同基因的对达托霉素敏感和对达托霉素不敏感（DNS）的耐甲氧西林金黄色葡萄球菌（MRSA）菌株的杀伤活性。然而，当使用高接种量的DNS菌株时，在我们的实验中未观察到明显的杀伤作用。细胞色素结合试验表明，在所使用的浓度下，d-环丝氨酸是唯一与两种菌株细胞表面电荷减少相关的活性剂。