在与细胞表面电荷减少相关的机制中，d-环丝氨酸可增强达托霉素对耐甲氧西林金黄色葡萄球菌的活性。
Daptomycin Activity against Methicillin-Resistant Staphylococcus aureus Is Enhanced by d-Cycloserine in a Mechanism Associated with a Decrease in Cell Surface Charge.
作者信息
Gasch O, Pillai S K, Dakos J, Miyakis S, Moellering R C, Eliopoulos G M
机构信息
Beth Israel Deaconess Medical Center
Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Antimicrob Agents Chemother. 2013 Sep;57(9):4537-4539. doi: 10.1128/AAC.00799-13. Epub 2013 Jun 24.
Abstract
The killing activity of daptomycin against an isogenic pair of daptomycin-susceptible and daptomycin-nonsusceptible (DNS) methicillin-resistant (MRSA) strains was enhanced by the addition of certain cell wall agents at 1× MIC. However, when high inocula of the DNS strain were used, no significant killing was observed in our experiments. Cytochrome binding assays revealed d-cycloserine as the only agent associated with a reduction in the cell surface charge for both strains at the concentrations used.
摘要
在1×最小抑菌浓度（MIC）下添加某些细胞壁活性剂可增强达托霉素对一对同基因的对达托霉素敏感和对达托霉素不敏感（DNS）的耐甲氧西林金黄色葡萄球菌（MRSA）菌株的杀伤活性。然而，当使用高接种量的DNS菌株时，在我们的实验中未观察到明显的杀伤作用。细胞色素结合试验表明，在所使用的浓度下，d-环丝氨酸是唯一与两种菌株细胞表面电荷减少相关的活性剂。
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