Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
EMBO Rep. 2010 Oct;11(10):744-50. doi: 10.1038/embor.2010.147. Epub 2010 Sep 24.
For innate and adaptive immune responses it is essential that inflammatory cells use quick and flexible locomotion strategies. Accordingly, most leukocytes can efficiently infiltrate and traverse almost every physiological or artificial environment. Here, we review how leukocytes might achieve this task mechanistically, and summarize recent findings on the principles of cytoskeletal force generation and transduction at the leading edge of leukocytes. We propose a model in which the cells switch between adhesion-receptor-mediated force transmission and locomotion modes that are based on cellular deformations, but independent of adhesion receptors. This plasticity in migration strategies allows leukocytes to adapt to the geometry and molecular composition of their environment.
对于先天免疫和适应性免疫反应而言，炎症细胞采用快速且灵活的运动策略至关重要。因此，大多数白细胞能够有效地渗透和穿越几乎所有生理或人工环境。在此，我们综述了白细胞如何在机制上实现这一任务，并总结了关于白细胞前缘细胞骨架力生成和转导原理的最新发现。我们提出了一个模型，即细胞在基于细胞变形但不依赖于黏附受体的黏附受体介导的力传递和运动模式之间进行切换。这种迁移策略的灵活性使白细胞能够适应其环境的几何形状和分子组成。
