Department of Clinical Medicine, University of Tromsø, Tromsø, Norway. Sigbjorn.Rogne @ unn.no
Dement Geriatr Cogn Disord. 2013;36(1-2):87-98. doi: 10.1159/000350408. Epub 2013 Jun 15.
BACKGROUND/AIMS: Late-onset Alzheimer's disease (LOAD) comprises sporadic LOAD and familial LOAD. We wanted to determine whether total plasma homocysteine (Hcy), cardiovascular risk factors and volumetric analyses of cerebral magnetic resonance imaging (MRI) were differently associated with mild cognitive impairment (MCI) in subjects from families with aggregation of LOAD (probable familial LOAD) and MCI in subjects from families without LOAD (probable sporadic LOAD).
A total of 103 subjects with MCI without known stroke or other apparent causative diseases were included as cases together with 58 controls. The cases were stratified into 3 groups according to the number of biological relatives with probable LOAD on one side of the family. Cerebral MRI was obtained from all. The case groups were compared to the control group in sex-specific analyses of covariance.
Hcy was significantly elevated in all cases compared to controls, except for women with probable familial LOAD. These women also had significantly smaller hippocampal volume and significantly larger lateral ventricles, unlike the women in the other case groups.
Our findings suggest that research on Hcy, cardiovascular risk factors and other potential risk factors for LOAD might benefit from distinguishing between sporadic and familial LOAD.
背景/目的：迟发性阿尔茨海默病（LOAD）包括散发性 LOAD 和家族性 LOAD。我们想确定总血浆同型半胱氨酸（Hcy）、心血管危险因素和磁共振成像（MRI）的容积分析是否与 LOAD 聚集家族中的轻度认知障碍（MCI）（可能的家族性 LOAD）和无 LOAD 家族中的 MCI（可能的散发性 LOAD）患者的 MCI 有不同的相关性。
共有 103 名无已知中风或其他明显病因疾病的 MCI 患者作为病例与 58 名对照一起纳入研究。根据家庭一侧具有 LOAD 可能性的生物学亲属数量，将病例分为 3 组。所有患者均进行 MRI 检查。在按性别进行的协方差分析中，将病例组与对照组进行比较。
除了具有家族性 LOAD 可能性的女性外，所有病例的 Hcy 均显著高于对照组。这些女性的海马体积也显著较小，侧脑室显著较大，与其他病例组的女性不同。
我们的研究结果表明，研究 Hcy、心血管危险因素和 LOAD 的其他潜在危险因素可能受益于区分散发性和家族性 LOAD。
