Department of Sleep and Psychology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Cell Biochem Biophys. 2013 Sep;67(1):169-73. doi: 10.1007/s12013-013-9529-4.
This study assessed the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients with chronic primary insomnia. Hundred and twenty patients with chronic primary insomnia were randomly assigned to three study groups (n = 40 per group): rTMS, medication, or psychotherapy treatment (both latter as controls). The treatments proceeded for 2 weeks, after which treatment efficacies were assessed in each study group based on changes in polysomnography parameters, Pittsburgh sleep quality index, and indices of HPA and HPT axes (serum cortisol, adrenocorticotropic hormone, highly sensitive thyrotropin, free T3, and free T4). Further, the relapse and recurrence rates within 3 months after respective treatments were also measured. rTMS treatment significantly better (p < 0.05) improved stage III sleep and REM sleep cycle compared with both control groups. Further, rTMS treatment group was more advantageous in improving the indices of HPA and HPT axes (p < 0.05 vs. both control groups). In addition, the relapse and recurrence rates were also the lowest in rTMS treatment group. In conclusion, rTMS treatment is more advantageous than both medication and psychotherapy treatments in improving the sleep architecture. Further, rTMS significantly decreases the body awakening level and provides a better long-term treatment effect.
这项研究评估了重复经颅磁刺激(rTMS)治疗慢性原发性失眠患者的疗效。120 名慢性原发性失眠患者被随机分为三组(每组 n = 40):rTMS 治疗组、药物治疗组和心理治疗组(后两者作为对照组)。治疗进行了 2 周,然后根据多导睡眠图参数、匹兹堡睡眠质量指数以及 HPA 和 HPT 轴的指标(血清皮质醇、促肾上腺皮质激素、高敏促甲状腺激素、游离 T3 和游离 T4)评估每个研究组的治疗效果。此外,还测量了各自治疗后 3 个月内的复发和复发率。rTMS 治疗组与对照组相比,III 期睡眠和 REM 睡眠周期明显改善(p < 0.05)。此外,rTMS 治疗组在改善 HPA 和 HPT 轴的指标方面也具有优势(p < 0.05 与两组对照组相比)。此外,rTMS 治疗组的复发和复发率也最低。总之,rTMS 治疗在改善睡眠结构方面比药物和心理治疗更有优势。此外,rTMS 还显著降低了身体觉醒水平,提供了更好的长期治疗效果。