Department of Chemotherapy, Zhejiang Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, People's Republic of China.
Med Oncol. 2013;30(3):645. doi: 10.1007/s12032-013-0645-1. Epub 2013 Jun 25.
A new lung adenocarcinoma classification proposed by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) has recently been published. However, the relationship between EGFR mutations and subtype of adenocarcinoma remains unclear. A total of 161 surgically resected lung adenocarcinomas in Zhejiang Cancer Hospital were reviewed using the new classification system. Epidermal growth factor receptor (EGFR) mutations were observed in 67 cases (41.6 %). EGFR mutations were found to be closely associated with the micropapillary predominant subtype (P = 0.0068) and lepidic component (P = 0.005). The frequency of EGFR mutation was found to be lower in the solid predominant subtype than other subtype (P = 0.04). In conclusion, histologic subtyping was found to be associated with EGFR mutations. The EGFR mutation frequency of micropapillary and lepidic predominant subtypes was found to be more pronounced than that of other subtypes.
最近发表了国际肺癌研究协会、美国胸科学会和欧洲呼吸学会（IASLC/ATS/ERS）提出的一种新的肺腺癌分类。然而，EGFR 突变与肺腺癌亚型之间的关系仍不清楚。本研究回顾性分析了浙江肿瘤医院 161 例手术切除的肺腺癌，采用新的分类系统。共观察到 67 例（41.6%）表皮生长因子受体（EGFR）突变。EGFR 突变与微乳头优势型（P=0.0068）和贴壁生长型（P=0.005）密切相关。实性为主型的 EGFR 突变频率低于其他亚型（P=0.04）。结论：组织学亚型与 EGFR 突变有关。微乳头型和贴壁型的 EGFR 突变频率高于其他亚型。
