Department of Computer Science, School of Electronics and Information Engineering, Tongji University, Shanghai 201804, China.
Database (Oxford). 2013 Jun 22;2013:bat042. doi: 10.1093/database/bat042. Print 2013.
Fusarium graminearum is a plant pathogen, which causes crop diseases and further leads to huge economic damage worldwide in past decades. Recently, the accumulation of different types of molecular data provides insights into the pathogenic mechanism of F. graminearum, and might help develop efficient strategies to combat this destructive fungus. Unfortunately, most available molecular data related to F. graminearum are distributed in various media, where each single source only provides limited information on the complex biological systems of the fungus. In this work, we present a comprehensive database, namely eFG (Electronic resource for Fusarium graminearum), to the community for further understanding this destructive pathogen. In particular, a large amount of functional genomics data generated by our group is deposited in eFG, including protein subcellular localizations, protein-protein interactions and orthologous genes in other model organisms. This valuable knowledge can not only help to disclose the molecular underpinnings of pathogenesis of the destructive fungus F. graminearum but also help the community to develop efficient strategies to combat this pathogen. To our best knowledge, eFG is the most comprehensive functional genomics database for F. graminearum until now. The eFG database is freely accessible at http://csb.shu.edu.cn/efg/ with a user-friendly and interactive interface, and all data can be downloaded freely. DATABASE URL: http://csb.shu.edu.cn/efg/
禾谷镰刀菌是一种植物病原体,它在过去几十年中导致了作物病害,并在全球范围内造成了巨大的经济损失。最近,不同类型的分子数据的积累为禾谷镰刀菌的致病机制提供了深入的了解,并可能有助于开发有效的策略来对抗这种破坏性真菌。不幸的是,大多数可用的与禾谷镰刀菌相关的分子数据分布在各种媒体中,每个单一来源仅提供有关真菌复杂生物系统的有限信息。在这项工作中,我们向社区展示了一个全面的数据库,即 eFG(禾谷镰刀菌电子资源),以帮助进一步了解这种破坏性病原体。特别是,我们小组生成的大量功能基因组学数据都存储在 eFG 中,包括蛋白质亚细胞定位、蛋白质-蛋白质相互作用以及其他模式生物中的同源基因。这些有价值的知识不仅有助于揭示破坏性真菌禾谷镰刀菌发病机制的分子基础,还有助于社区开发有效的策略来对抗这种病原体。据我们所知,eFG 是迄今为止最全面的禾谷镰刀菌功能基因组学数据库。eFG 数据库可在 http://csb.shu.edu.cn/efg/ 免费访问,具有用户友好和交互式的界面,并且所有数据均可免费下载。数据库 URL:http://csb.shu.edu.cn/efg/