形态发生素梯度的数学模型及其对基因表达的影响。
Mathematical models of morphogen gradients and their effects on gene expression.
作者信息
Shvartsman Stanislav Y, Baker Ruth E
机构信息
Department of Chemical and Biological Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ, USA.
出版信息
Wiley Interdiscip Rev Dev Biol. 2012 Sep-Oct;1(5):715-30. doi: 10.1002/wdev.55. Epub 2012 Apr 12.
An introduction to mathematical models of pattern formation by morphogen gradients is presented, using the early embryo of the fruit fly Drosophila as the main experimental example. Analysis of morphogen gradient formation is based on the source-diffusion-degradation models and a formalism of local accumulation times. Transcriptional control by morphogens is discussed within the framework of thermodynamic site occupancy models of gene regulatory regions.
本文以果蝇早期胚胎为主要实验实例，介绍了形态发生素梯度形成模式的数学模型。形态发生素梯度形成的分析基于源-扩散-降解模型和局部积累时间的形式体系。在基因调控区域的热力学位点占据模型框架内讨论了形态发生素的转录控制。
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