Angstman Kurt B, Wade Todd W, Dejesus Ramona S, Rundell James R, Altrichter Paul M
Department of Family Medicine, Mayo Clinic, Rochester, MN 55906, USA.
J Prim Care Community Health. 2013 Apr 1;4(2):119-23. doi: 10.1177/2150131912454012. Epub 2012 Jul 17.
Obesity and depression are often comorbid conditions. There appears to be a bidirectional relationship between these. Obesity at baseline has been shown to increase the risk of onset of depression and depression at baseline increased the odds for developing obesity. Less is understood about the impact of obesity on depression treatment outcomes. The authors' hypothesis was that obesity (body mass index [BMI] ≥ 30 kg/m²) and morbid obesity (BMI ≥ 40 kg/m²) would each have negative effects on depression remission rates after 6 months of enrollment into collaborative care management for depression. In a retrospective analysis of 1111 depressed patients with a PHQ-9 (Patient Health Questionnaire) score of 10 or greater, multivariate analysis for the odds ratio of achieving remission at 6 months demonstrated that the patient's BMI at baseline was not an independent risk factor for depression outcome at 6 months. Collaborative care management for depression has been shown to be effective for improving depression outcomes, yet minimal prior research has focused on other clinical comorbidities that might affect outcomes. Although obesity was common in the study population, it was reassuring, based on this study that 6-month depression treatment outcomes do not appear to be significantly affected by the patient's baseline BMI.
肥胖和抑郁症常常并存。这两者之间似乎存在双向关系。研究表明，基线时肥胖会增加患抑郁症的风险，而基线时患有抑郁症则会增加患肥胖症的几率。关于肥胖对抑郁症治疗效果的影响，人们了解得较少。作者的假设是，肥胖（体重指数[BMI]≥30kg/m²）和病态肥胖（BMI≥40kg/m²）在纳入抑郁症协作护理管理6个月后，均会对抑郁症缓解率产生负面影响。在一项对1111名PHQ-9（患者健康问卷）评分≥10的抑郁症患者的回顾性分析中，对6个月时实现缓解的比值比进行多变量分析表明，患者的基线BMI并非6个月时抑郁症治疗结果的独立危险因素。抑郁症协作护理管理已被证明对改善抑郁症治疗效果有效，但此前很少有研究关注可能影响治疗效果的其他临床合并症。尽管肥胖在研究人群中很常见，但基于这项研究令人欣慰的是，患者的基线BMI似乎并未对6个月的抑郁症治疗结果产生显著影响。
