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采用高效液相色谱/紫外/质谱联用技术结合主成分分析法对首乌藤进行质量评价。

Quality assessment on Polygoni Multiflori Caulis using HPLC/UV/MS combined with principle component analysis.

作者信息

Zhao Yang, Kao Chun-Pin, Chang Yuan-Shiun, Ho Yu-Ling

机构信息

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan.

出版信息

Chem Cent J. 2013 Jun 24;7(1):106. doi: 10.1186/1752-153X-7-106.

DOI:10.1186/1752-153X-7-106
PMID:23800018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3695832/
Abstract

BACKGROUND

Polygoni Multiflori Caulis, the dried caulis of Polygonum multiflorum Thunb., is one of the commonly used traditional Chinese medicines having antioxidant, anti-obesity, anti-inflammatory and antibacterial effects. Polygoni Multiflori Caulis used clinically or circulated on market have great differences in their diameters. However, to the best of our knowledge, no study has been reported on the qualities of Polygoni Multiflori Caulis with different diameters.

RESULTS

Systematic HPLC/UV/MS chromatographic fingerprinting and quantitative analytical methods combined with principal component analysis were developed and applied to analyze different Polygoni Multiflori Caulis samples. The contents of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, the chemical marker for quality control on Polygoni Multiflori Caulis specified in Chinese Pharmacopoeia (2010 edition), were found to have surprising relevance with the samples' diameters for the first time.

CONCLUSION

The finding provides a scientific basis for collecting Polygoni Multiflori Caulis in the best time. Moreover, the diameter can be used as the criterion for quality control on Polygoni Multiflori Caulis as a preliminary step in the future. In addition, scores plot obtained from principal component analysis shows the obvious differences between unqualified Polygoni Multiflori Caulis samples and qualified ones visually, which can be used to single out the unqualified ones with qualified ones efficiently and immediately.

摘要

背景

首乌藤为蓼科植物何首乌干燥藤茎，是常用的传统中药之一，具有抗氧化、抗肥胖、抗炎及抗菌作用。临床使用或市场流通的首乌藤直径差异较大。然而，据我们所知，尚无关于不同直径首乌藤质量的研究报道。

结果

建立了系统的高效液相色谱/紫外/质谱色谱指纹图谱及定量分析方法，并结合主成分分析用于分析不同的首乌藤样品。首次发现《中国药典》（2010年版）规定的首乌藤质量控制化学指标成分2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的含量与样品直径存在惊人的相关性。

结论

该发现为最佳采收期采集首乌藤提供了科学依据。此外，直径可作为首乌藤质量控制的标准，作为未来的初步步骤。另外，主成分分析得到的得分图直观显示了不合格首乌藤样品与合格样品之间的明显差异，可用于高效、快速地从合格样品中筛选出不合格样品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/09dfbf9d73ed/1752-153X-7-106-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/7012488dc32a/1752-153X-7-106-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/e00c4995f58a/1752-153X-7-106-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/3d6292c27c27/1752-153X-7-106-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/57fbd2425f8a/1752-153X-7-106-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/3d690cf5373c/1752-153X-7-106-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/91bbdedb3fa4/1752-153X-7-106-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/09dfbf9d73ed/1752-153X-7-106-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/7012488dc32a/1752-153X-7-106-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/e00c4995f58a/1752-153X-7-106-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/3d6292c27c27/1752-153X-7-106-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/57fbd2425f8a/1752-153X-7-106-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/3d690cf5373c/1752-153X-7-106-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/91bbdedb3fa4/1752-153X-7-106-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ae9/3695832/09dfbf9d73ed/1752-153X-7-106-7.jpg

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