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个性化菌斑控制管理口腔扁平苔藓牙龈表现的成本效益:一项随机对照研究。

Cost-effectiveness of personalized plaque control for managing the gingival manifestations of oral lichen planus: a randomized controlled study.

机构信息

School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK.

出版信息

J Clin Periodontol. 2013 Sep;40(9):859-67. doi: 10.1111/jcpe.12126. Epub 2013 Jun 25.

Abstract

AIM

To undertake cost-effectiveness and cost-benefit analyses of an intervention to improve oral health in patients presenting with the gingival manifestations of oral lichen planus (OLP).

MATERIALS & METHODS: Eighty-two patients were recruited to a 20-week randomized controlled trial. The intervention was personalized plaque control comprising powered tooth brushing and inter-dental cleaning advice. The primary outcome measure was the oral health impact profile (OHIP) with secondary outcomes of pain, plaque index, mucosal disease score and cost-effectiveness. Private cost data and stated willingness-to-pay (WTP) values for treatment were obtained from intervention patients at 20 weeks.

RESULTS

Overall, 81% of intervention patients showed improvement in both plaque index and mucosal disease score at 20 weeks compared to 30% of controls that continued with their usual plaque control regimen. All intervention group patients stated a positive WTP value. The mean net value of the treatment was £172 compared to the incremental cost of the treatment estimated at £122.75. The cost-effectiveness analysis resulted in an incremental cost-effectiveness ratio of £13 per OHIP point.

CONCLUSIONS

The tailored plaque control programme was more effective than control in treating the gingival manifestations of oral lichen planus. The programme is cost effective for modest values placed on a point on the OHIP scale and patients generally valued the treatment in excess of the cost.

摘要

目的

对改善口腔扁平苔藓(OLP)患者牙龈表现的干预措施进行成本效益和成本效益分析。

材料与方法

82 名患者参加了为期 20 周的随机对照试验。干预措施是个性化的菌斑控制,包括强力刷牙和牙间清洁建议。主要结局指标是口腔健康影响量表(OHIP),次要结局指标是疼痛、菌斑指数、黏膜疾病评分和成本效益。在 20 周时,从干预组患者处获得了私人成本数据和对治疗的意愿支付(WTP)值。

结果

总体而言,与继续使用常规菌斑控制方案的对照组相比,20 周时,81%的干预组患者在菌斑指数和黏膜疾病评分方面均有改善,而对照组仅为 30%。所有干预组患者均表示愿意支付积极的 WTP 值。治疗的平均净价值为 172 英镑,而治疗的增量成本估计为 122.75 英镑。成本效益分析得出每 OHIP 点 13 英镑的增量成本效益比。

结论

定制的菌斑控制方案在治疗口腔扁平苔藓的牙龈表现方面比对照组更有效。对于在 OHIP 量表上的一个点上赋予的适度价值,该方案具有成本效益,并且患者普遍对治疗的价值超过了成本。

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