School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK.
J Clin Periodontol. 2015 Apr;42(4):356-62. doi: 10.1111/jcpe.12385. Epub 2015 Apr 10.
To evaluate the impact of a structured plaque control intervention on clinical and patient-centred outcomes for patients with gingival manifestations of oral lichen planus.
Eighty-two patients were recruited into a 20-week randomized controlled trial. The intervention was structured plaque control comprising powered tooth brushing and inter-dental cleaning advice. Control subjects continued with their normal dental plaque control regimen. The primary outcome measure was the oral health impact profile (OHIP) with secondary outcomes of pain, plaque index, mucosal disease score and cost-effectiveness.
Overall, the intervention patients showed statistically significant improvements in OHIP sum ordinal and OHIP dichotomous scores compared with control. There were improvements in the functional limitation, psychological discomfort and physical disability domains at 4- and 20-weeks and in the psychological disability domain at 20-weeks. The intervention was successful in reducing plaque compared to control (p < 0.001) and improvements were observed using the mucosal disease indices at the 4- and 20-week follow-ups (p < 0.001).
A structured plaque control intervention was effective in improving the oral health-related quality of life and clinically observed gingival lesions. This study provides evidence to include intensive plaque control within patients' initial and on-going management.
评估结构化菌斑控制干预对口腔扁平苔藓牙龈表现患者的临床和以患者为中心的结局的影响。
82 名患者被纳入一项 20 周的随机对照试验。干预措施为结构性菌斑控制,包括强力刷牙和牙间清洁建议。对照组继续采用常规的口腔菌斑控制方案。主要结局测量指标为口腔健康影响简表(OHIP),次要结局测量指标为疼痛、菌斑指数、黏膜疾病评分和成本效益。
总体而言,与对照组相比,干预组患者的 OHIP 总分和 OHIP 二分变量评分均有统计学意义的改善。在 4 周和 20 周时,在功能受限、心理不适和身体残疾领域以及在 20 周时的心理残疾领域均有改善。与对照组相比,干预组在减少菌斑方面更为成功(p<0.001),并且在 4 周和 20 周的随访中,使用黏膜疾病指数观察到了改善(p<0.001)。
结构化菌斑控制干预措施可有效改善口腔健康相关生活质量和临床观察到的牙龈病变。本研究为将强化菌斑控制纳入患者初始和持续管理提供了证据。